{"id":"W2156954694","doi":"10.2147/dddt.s89338","title":"A novel small-molecule inhibitor of HIV-1 entry","year":2015,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; McGill University","keywords":"Human immunodeficiency virus (HIV); Small molecule; Drug; Drug resistance; Antiretroviral therapy; ANTIRETROVIRAL AGENTS; Pharmacology; Lentivirus; Medicine; Virology; Chemistry; Viral load; Biology; Viral disease; Biochemistry; Microbiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009158356,0.0004979582,0.0003615864,0.0002053967,0.0001392604,0.0002265389,0.0004340941,0.000288002,0.003559854],"category_scores_gemma":[0.00008028123,0.0001049721,0.0002021481,0.0001690777,0.0001480738,0.0002128045,0.0002735508,0.0005034018,0.001216481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215169,"about_ca_system_score_gemma":0.0002962603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004113727,"about_ca_topic_score_gemma":0.0009344558,"domain_scores_codex":[0.9999514,0.00000418871,0.000004708379,0.00001099077,0.00001609749,0.00001271084],"domain_scores_gemma":[0.9999741,0.000003275122,0.000004929974,0.000001780198,0.000003818416,0.00001216032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001032761,0.0004401518,0.0006188531,0.0007838155,0.00002623275,0.0008708903,0.00006435425,0.0008852681,0.905426,0.001280951,0.001942558,0.08662824],"study_design_scores_gemma":[0.005413638,0.02331793,0.01393931,0.0003076783,0.0002625831,0.01304632,0.00009743438,0.006281215,0.7907525,0.001315843,0.1451843,0.00008120554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9305273,0.03003449,0.007072862,0.0008104584,0.000358065,0.000528376,0.001745545,0.0004878302,0.02843504],"genre_scores_gemma":[0.9335199,0.0240169,0.01183541,0.0006817195,0.0001472801,0.0002294518,0.004139154,0.00003023873,0.02540007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003559854,"threshold_uncertainty_score":0.01190889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0504161142988806,"score_gpt":0.2532795494322457,"score_spread":0.2028634351333651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}