{"id":"W2156995088","doi":"10.1074/jbc.m102403200","title":"Superinhibition of Sarcoplasmic Reticulum Function by Phospholamban Induces Cardiac Contractile Failure","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"Phospholamban; Internal medicine; Heart failure; Endocrinology; Endoplasmic reticulum; Muscle hypertrophy; Ryanodine receptor 2; Cardiac function curve; Biology; Cardiomyopathy; Genetically modified mouse; Transgene; Ryanodine receptor; Chemistry; Medicine; Calcium; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184275,0.000124456,0.0004873692,0.00001956147,0.00003705783,0.000005349367,0.00004733451,0.0003136998,0.0004293167],"category_scores_gemma":[0.0001762656,0.00008510547,0.0003255648,0.0001093691,0.0001408352,0.00006059659,0.00001534855,0.0005211516,0.000004330938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004997149,"about_ca_system_score_gemma":0.00005709979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002254019,"about_ca_topic_score_gemma":4.899557e-8,"domain_scores_codex":[0.9991081,0.00004198335,0.0003845009,0.0001367554,0.0001523108,0.0001763881],"domain_scores_gemma":[0.9992399,0.00008232098,0.0002806204,0.0001054566,0.0001815832,0.0001101516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001132443,0.0001236036,0.003094586,0.00002589299,0.0001191203,0.0001063922,0.00001063307,0.000003244086,0.9895487,0.000003028557,0.005036835,0.0007955532],"study_design_scores_gemma":[0.0008253941,0.0008135231,0.01011681,0.00007431248,0.0001086819,0.001510868,0.0001901585,0.000002219686,0.979387,0.0000894827,0.006786857,0.00009469661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970084,0.001469243,0.00002530054,0.0004962776,0.0001238396,0.00006182631,0.00001448254,0.00001192173,0.0007886362],"genre_scores_gemma":[0.9983756,0.0007854661,0.00004612572,0.0001156651,0.0005012116,0.000003212705,0.00003820048,0.000006382401,0.0001281197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01016167,"threshold_uncertainty_score":0.4700717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00815529352647916,"score_gpt":0.225393616148424,"score_spread":0.2172383226219448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}