{"id":"W2157037954","doi":"10.1124/mol.111.073833","title":"Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter","year":2011,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Barbara Ann Karmanos Cancer Institute; Mesothelioma Applied Research Foundation","keywords":"HeLa; Antifolate; Chemistry; Pyrimidine; Symporter; Cell culture; In vivo; Pemetrexed; Molecular biology; In vitro; Transporter; Biochemistry; Biology; Antimetabolite; Gene; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557178,0.0002542606,0.0004299693,0.000194338,0.0001899328,0.0003088435,0.0003809809,0.0005353137,0.000808094],"category_scores_gemma":[0.0001063291,0.0001571161,0.000230075,0.0001305088,0.0001808937,0.0002042674,0.0001266451,0.0004434137,0.0002634852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004816398,"about_ca_system_score_gemma":0.0002584949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001572456,"about_ca_topic_score_gemma":0.003074673,"domain_scores_codex":[0.9999244,0.00001777486,0.000003725291,0.00001614549,0.00001168034,0.00002626293],"domain_scores_gemma":[0.9999628,0.000007602125,0.000009192126,0.000005120298,0.000004576471,0.00001078724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009352891,0.000140372,0.000160933,0.0001066961,0.00002557591,0.0002650211,0.0000643215,0.0007329004,0.986926,0.0004810298,0.0003019822,0.009859974],"study_design_scores_gemma":[0.0003437208,0.004031766,0.001314768,0.000009817164,0.00008495907,0.0007160546,0.00002296634,0.003529696,0.9811368,0.00006810122,0.008725183,0.00001610032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877906,0.004058605,0.004593795,0.0003549968,0.0001010627,0.0001031871,0.0002138039,0.0001524726,0.002631415],"genre_scores_gemma":[0.9940332,0.001487196,0.002158133,0.00005646603,0.00001750797,0.00002873872,0.0001645889,0.00001314495,0.002041116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572456,"threshold_uncertainty_score":0.003494501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04081051129068206,"score_gpt":0.3399722901518558,"score_spread":0.2991617788611737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}