{"id":"W2157037954","doi":"10.1124/mol.111.073833","title":"Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter","year":2011,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Barbara Ann Karmanos Cancer Institute; Mesothelioma Applied Research Foundation","keywords":"HeLa; Antifolate; Chemistry; Pyrimidine; Symporter; Cell culture; In vivo; Pemetrexed; Molecular biology; In vitro; Transporter; Biochemistry; Biology; Antimetabolite; Gene; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006948114,0.0003547691,0.0006010394,0.0003371732,0.0001992004,0.00001123615,0.0003723988,0.0001755567,0.00053568],"category_scores_gemma":[0.00003241891,0.0002534316,0.0002251071,0.0007334193,0.0002247267,0.00005537561,0.00004443878,0.0006644357,0.0000270281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007650485,"about_ca_system_score_gemma":0.0001924779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001782433,"about_ca_topic_score_gemma":0.00000680883,"domain_scores_codex":[0.9974808,0.0001631017,0.0005801877,0.0005726142,0.0004561942,0.0007471702],"domain_scores_gemma":[0.9988679,0.00005996949,0.0001678903,0.000361036,0.0003106476,0.0002325607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002291932,0.001390659,0.000540646,0.0001022137,0.0004888432,0.0002639458,0.0009674361,0.0001868762,0.9930591,0.00005529997,0.0003468642,0.0003061891],"study_design_scores_gemma":[0.005429978,0.002734533,0.005438624,0.00005638442,0.0003656872,0.00002760338,0.00004194358,0.01920098,0.9659033,0.00003059476,0.0005132385,0.000257168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906569,0.0001400846,0.003576307,0.0009672,0.0001142998,0.003373798,0.00002677268,0.00008014061,0.001064461],"genre_scores_gemma":[0.9953232,0.000009651554,0.0003364373,0.003620447,0.00005053213,0.0004210706,0.0000580569,0.00007720521,0.0001034028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02715583,"threshold_uncertainty_score":0.9999918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04081051129068206,"score_gpt":0.3399722901518558,"score_spread":0.2991617788611737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}