{"id":"W2157064963","doi":"10.1586/ern.10.27","title":"Causes versus effects: the increasing complexities of Alzheimer’s disease pathogenesis","year":2010,"lang":"en","type":"review","venue":"Expert Review of Neurotherapeutics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute on Aging","keywords":"Pathogenesis; Disease; Etiology; Amyloid β; Medicine; Neuroscience; Alzheimer's disease; Bioinformatics; Pathology; Psychology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003674354,0.0006817989,0.003045186,0.0001596179,0.000116394,0.00001734631,0.000442908,0.000163373,0.0001259636],"category_scores_gemma":[0.0004134196,0.0003864166,0.001564111,0.0004128799,0.0005469464,0.00005203991,0.000137329,0.0004749804,0.00002678706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004446715,"about_ca_system_score_gemma":0.001029413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003522798,"about_ca_topic_score_gemma":0.000001688753,"domain_scores_codex":[0.9960748,0.001077195,0.001102024,0.0004596967,0.000867125,0.0004191776],"domain_scores_gemma":[0.9957623,0.001313819,0.0007500406,0.001506241,0.0002630123,0.0004045839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002582934,0.0005531124,0.00001856854,0.1472519,0.01004722,0.0001442241,0.00003200308,9.47152e-9,0.000008864774,0.000105832,0.0003488871,0.841231],"study_design_scores_gemma":[0.0006976234,0.0003813622,0.00009116131,0.1166711,0.01988277,0.00005865229,0.00000762188,0.000001324636,0.00003433446,0.000009057857,0.861901,0.0002640251],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000016391,0.9949356,0.000002290423,0.0002431857,0.0003324683,0.004004446,0.0002391501,0.00003926857,0.0001872095],"genre_scores_gemma":[0.00004218227,0.997701,0.0002716664,0.0008606414,0.0002897796,0.0004867947,0.0001864538,0.0001529694,0.000008492767],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8615521,"threshold_uncertainty_score":0.9998588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1455675701228045,"score_gpt":0.4377075230352109,"score_spread":0.2921399529124064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}