{"id":"W2157103902","doi":"10.1016/j.bmc.2013.08.068","title":"Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Mineralocorticoid receptor; Mineralocorticoid; Steroid; Antagonist; Pharmacology; Dehydrogenase; Receptor; Reductive amination; Steric effects; Enzyme; Stereochemistry; Biochemistry; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002914359,0.0002612567,0.0005219518,0.00005941831,0.00007114195,0.00002319026,0.0000673317,0.0001899868,0.0007225636],"category_scores_gemma":[0.0006879964,0.0002098477,0.0000501465,0.000172209,0.0003515285,0.000119875,0.00006792066,0.0001517316,0.00002136478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009183788,"about_ca_system_score_gemma":0.0001918879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000100255,"about_ca_topic_score_gemma":0.000002013548,"domain_scores_codex":[0.9980574,0.00005884704,0.000551336,0.0004180543,0.0006678216,0.0002465158],"domain_scores_gemma":[0.9986426,0.0001201285,0.0002408579,0.0002679866,0.0003351637,0.0003932463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001200995,0.0001152963,0.005721902,0.000295218,0.00007203112,0.00001531611,0.0002837854,5.403779e-8,0.9725468,0.00000194688,0.0002478826,0.02057965],"study_design_scores_gemma":[0.001571392,0.0002712006,0.05615209,0.0004684717,0.0002768509,0.0006641216,0.0007316227,0.0005465464,0.9386893,0.00002535583,0.0004005501,0.000202509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949993,0.00196325,0.000008500295,0.002003103,0.00004508936,0.0005508516,0.000005892586,0.00003653501,0.0003874076],"genre_scores_gemma":[0.9985806,0.0002378714,0.000397771,0.0002201634,0.000173558,0.00005422606,0.00004306767,0.00003105592,0.0002616755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05043019,"threshold_uncertainty_score":0.8557342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324814177775915,"score_gpt":0.2526922556765029,"score_spread":0.2394441138987437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}