{"id":"W2157129485","doi":"10.1093/jac/dkr021","title":"Analysis of mutations in multiple loci of Neisseria gonorrhoeae isolates reveals effects of PIB, PBP2 and MtrR on reduced susceptibility to ceftriaxone","year":2011,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Saskatchewan","keywords":"MTRR; Neisseria gonorrhoeae; Ceftriaxone; Neisseriaceae; Microbiology; Biology; Genetics; Neisseria; Cephalosporin; Gonorrhea; Antibacterial agent; Gene; Antibiotics; Bacteria; Genotype; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001512084,0.0002395301,0.0001913609,0.000379878,0.0001240823,0.0001310196,0.0001123293,0.0001718122,0.0005215018],"category_scores_gemma":[0.0003336717,0.0001131419,0.0001634186,0.0002674188,0.0001468208,0.0000655091,0.0001264242,0.0001537743,0.00007666319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409404,"about_ca_system_score_gemma":0.0001501581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004466206,"about_ca_topic_score_gemma":0.007310314,"domain_scores_codex":[0.9998622,0.00002229781,0.00001335207,0.00003337996,0.0000418354,0.00002697284],"domain_scores_gemma":[0.9997564,0.00003850112,0.00009900848,0.00001721903,0.00003968746,0.00004918376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006864167,0.0001147551,0.5207788,0.00006287142,0.00009596104,0.000846615,0.0003250061,0.000165288,0.4693797,0.00002363777,0.00009198335,0.007428963],"study_design_scores_gemma":[0.00001086649,0.0002050811,0.9866455,0.00000355037,0.00002133017,0.000739126,0.00008256279,0.0001950058,0.01193122,0.000003727401,0.0001593789,0.00000261877],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997842,0.00003953934,0.00004982559,0.000004342784,6.040193e-7,0.000003515204,0.00005777274,0.000001800868,0.00005844733],"genre_scores_gemma":[0.9995502,0.00003289276,0.0001358522,0.000008331906,0.000001136255,0.000003400848,0.000185288,9.822072e-7,0.00008185115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004466206,"threshold_uncertainty_score":0.008880436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02359313300525971,"score_gpt":0.2885009503720692,"score_spread":0.2649078173668095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}