{"id":"W2157186191","doi":"10.1371/journal.pone.0100776","title":"Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function","year":2014,"lang":"en","type":"review","venue":"PLoS ONE","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Freiwillige Akademische Gesellschaft; National Institute of Allergy and Infectious Diseases; National Institute of Nursing Research; National Human Genome Research Institute; Biotechnology and Biological Sciences Research Council; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; University of Edinburgh; Uppsala Multidisciplinary Center for Advanced Computational Science; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Cambridge Institute for Medical Research, University of Cambridge; European Commission; Engineering and Physical Sciences Research Council; Uppsala Universitet; Abbott Diagnostics; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; Ministry of Cultural Affairs; Hjärt-Lungfonden; Universität Greifswald; Lungenliga Schweiz; Hjartavernd; Johns Hopkins University; Vetenskapsrådet; National Center for Advancing Translational Sciences; Economic and Social Research Council; Siemens; Bundesamt für Gesundheit; Scottish Government; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Svenska Läkaresällskapet; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Environmental Health Sciences; School of Medicine, Boston University; National Science Foundation; Royal Society; Flight Attendant Medical Research Institute; U.S. Public Health Service; Age UK; Wellcome Trust; Münchner Zentrum für Gesundheitswissenschaften; Stiftelsen för Strategisk Forskning; Bundesministerium für Bildung und Forschung; National Institute on Aging; Centre for Cognitive Ageing and Cognitive Epidemiology; National Institute for Health and Care Research; Juvenile Diabetes Research Foundation International","keywords":"Genome-wide association study; Locus (genetics); Genetic association; Genetics; Population; Biology; Medicine; Genotype; Internal medicine; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02547258,0.003351697,0.009491848,0.005026046,0.0009541952,0.003620302,0.002161443,0.002265888,0.002826612],"category_scores_gemma":[0.03559375,0.0014909,0.04003953,0.00797168,0.000729341,0.001304148,0.002032876,0.002983362,0.0003504428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001402416,"about_ca_system_score_gemma":0.001745494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005461802,"about_ca_topic_score_gemma":0.007271003,"domain_scores_codex":[0.982581,0.01031748,0.002275307,0.003224403,0.00110125,0.0005005399],"domain_scores_gemma":[0.9713557,0.02118867,0.002665395,0.00306425,0.001354169,0.0003717893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003554091,0.00003664821,0.05471874,0.00799444,0.9203894,0.0002123089,0.00006098423,0.002673539,0.0005854787,0.0001859635,0.001039638,0.008548785],"study_design_scores_gemma":[0.000756203,0.0002586268,0.03101106,0.0009927576,0.962384,0.0001778879,0.00004846143,0.001686904,0.0003318371,0.000935075,0.001388252,0.00002882436],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.146242,0.825841,0.01638041,0.0020518,0.0009195246,0.0003932103,0.00648336,0.0005838158,0.001104987],"genre_scores_gemma":[0.8785912,0.1006815,0.01249732,0.001233499,0.0006572438,0.0009494658,0.004657506,0.0002025207,0.0005297344],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02547258,"threshold_uncertainty_score":0.1347135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2398494115445582,"score_gpt":0.4063469638061342,"score_spread":0.166497552261576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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