{"id":"W2157200088","doi":"10.1124/jpet.110.173120","title":"Mechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Nontransformed Human Peripheral Lung Epithelial Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Human lung; Peripheral; Lung; Pharmacology; Amiodarone; Chemistry; Peripheral blood; Medicine; Immunology; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003860275,0.0002874016,0.0005316409,0.0004866871,0.0004068792,0.0008395555,0.0005842149,0.0005498006,0.001525123],"category_scores_gemma":[0.0002997123,0.0002659406,0.0006002093,0.0003192803,0.0003552337,0.0006735833,0.0003255643,0.0007850003,0.0004940086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006117763,"about_ca_system_score_gemma":0.0003019382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008723352,"about_ca_topic_score_gemma":0.0007403282,"domain_scores_codex":[0.9995332,0.0001295429,0.00005617528,0.00004889109,0.0001505989,0.00008162526],"domain_scores_gemma":[0.9996732,0.00009764802,0.00003840793,0.00008386735,0.00007232087,0.00003456155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003251707,0.00005762249,0.0003688022,0.00007070849,0.00001306944,0.0001913623,0.0000755603,0.0001122719,0.9960938,0.0006548506,0.00005172443,0.001985107],"study_design_scores_gemma":[0.00003483008,0.0005554004,0.01198139,0.000009626248,0.00002437789,0.0009372834,0.0001508423,0.001474293,0.983225,0.0002449699,0.001354033,0.000008015428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855804,0.006001904,0.005240378,0.0002151088,0.00005319743,0.0000752998,0.0004751992,0.0001852588,0.002173203],"genre_scores_gemma":[0.9955516,0.001135603,0.000769712,0.00004468128,0.00001132125,0.00005129662,0.0003342858,0.00001244267,0.002089106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525123,"threshold_uncertainty_score":0.005102098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149407749440217,"score_gpt":0.3049887389754998,"score_spread":0.2934946614810976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}