{"id":"W2157205995","doi":"10.1128/jvi.03288-14","title":"Mutational Analysis of Vaccinia Virus E3 Protein: the Biological Functions Do Not Correlate with Its Biochemical Capacity To Bind Double-Stranded RNA","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Canadian Institutes of Health Research; University of Texas Health Science Center at San Antonio","keywords":"Biology; RNA silencing; Interferon; RNA-binding protein; Protein kinase R; RNA; Viral replication; Virus; Antiviral protein; Molecular biology; Cell biology; Protein kinase A; Virology; Biochemistry; RNA interference; Kinase; Gene; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473359,0.0003714802,0.0001401977,0.0001405999,0.0001892015,0.0001635263,0.0001869374,0.0002763075,0.0006773749],"category_scores_gemma":[0.0003078925,0.00006901619,0.0002599893,0.0001039771,0.0003228736,0.0001417387,0.0001457013,0.0002653601,0.000286321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177047,"about_ca_system_score_gemma":0.0002219378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009051342,"about_ca_topic_score_gemma":0.0005249627,"domain_scores_codex":[0.999904,0.0000226944,0.00001380826,0.00001824534,0.00002638583,0.00001481713],"domain_scores_gemma":[0.9998329,0.00005429276,0.00004302942,0.00001746466,0.0000245429,0.00002775837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140387,0.0000283716,0.00177652,0.00005149785,0.000006938359,0.0001622506,0.00001650425,0.0001895625,0.996232,0.00007152522,0.00001799183,0.001306522],"study_design_scores_gemma":[0.0000151072,0.0002527726,0.01670788,0.00001139064,0.00003555648,0.001842579,0.00003586271,0.001347825,0.9776633,0.00005423268,0.002025071,0.000008495756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997472,0.0003274985,0.001600095,0.00005057916,0.00000696997,0.00001351095,0.0001618349,0.00001934532,0.0003480664],"genre_scores_gemma":[0.9972696,0.00020798,0.001893417,0.00001965415,0.000003279664,0.0000101465,0.0003656859,0.00001111213,0.0002189322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009051342,"threshold_uncertainty_score":0.00230515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06206034574189542,"score_gpt":0.2907873098795802,"score_spread":0.2287269641376848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}