{"id":"W2157205995","doi":"10.1128/jvi.03288-14","title":"Mutational Analysis of Vaccinia Virus E3 Protein: the Biological Functions Do Not Correlate with Its Biochemical Capacity To Bind Double-Stranded RNA","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Canadian Institutes of Health Research; University of Texas Health Science Center at San Antonio","keywords":"Biology; RNA silencing; Interferon; RNA-binding protein; Protein kinase R; RNA; Viral replication; Virus; Antiviral protein; Molecular biology; Cell biology; Protein kinase A; Virology; Biochemistry; RNA interference; Kinase; Gene; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009231384,0.0001686535,0.0005729868,0.0004492255,0.0001154516,0.0000134172,0.0003892985,0.0003457882,0.0005269941],"category_scores_gemma":[0.0003167208,0.00009118518,0.0002273947,0.0006402092,0.0003796081,0.00007790782,0.00007797946,0.0007809885,0.0001356443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005212066,"about_ca_system_score_gemma":0.0002187227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006485561,"about_ca_topic_score_gemma":0.00006058937,"domain_scores_codex":[0.998296,0.0003965078,0.00057907,0.000211317,0.000142806,0.0003743574],"domain_scores_gemma":[0.9984537,0.0002713126,0.0003989355,0.0002082172,0.0005263331,0.0001415184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01493497,0.0002539108,0.001111818,0.000003070767,0.002520119,0.00003088233,0.0004156598,0.0005888334,0.9782987,0.0003380046,0.001145573,0.0003584244],"study_design_scores_gemma":[0.01348253,0.009126618,0.1162901,0.00003556773,0.001657257,0.001402441,0.0004518729,0.0000704909,0.846014,0.0004862763,0.01057334,0.0004095506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962876,0.0004635467,0.0006706628,0.001777446,0.0001794119,0.0002431224,0.0001144346,0.000008620437,0.00025518],"genre_scores_gemma":[0.9993315,0.00001889929,0.0001023736,0.0002528037,0.00005949826,0.00001494391,0.00002375219,0.000007446658,0.0001888034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1322848,"threshold_uncertainty_score":0.5770216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06206034574189542,"score_gpt":0.2907873098795802,"score_spread":0.2287269641376848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}