{"id":"W2157234074","doi":"10.1002/anie.200705435","title":"A New Generation of Specific <i>Trypanosoma cruzi trans</i>‐Sialidase Inhibitors","year":2008,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Trypanosoma cruzi; Substituent; Sialidase; Chemistry; Chagas disease; Substitution (logic); Stereochemistry; Biochemistry; Biology; Enzyme; Virology; Neuraminidase; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478349,0.0005091784,0.0003425822,0.0001698007,0.0001592886,0.0003484194,0.0004185576,0.0004203824,0.001532368],"category_scores_gemma":[0.00009747752,0.0001612977,0.0002421765,0.0001298467,0.0002057122,0.0003266378,0.0002338063,0.0008828205,0.0006182483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003717189,"about_ca_system_score_gemma":0.0002550816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006538941,"about_ca_topic_score_gemma":0.001245585,"domain_scores_codex":[0.9999301,0.000007942938,0.000004603241,0.00001727262,0.00002120787,0.00001880279],"domain_scores_gemma":[0.9999555,0.000004789415,0.00001035844,0.000005732403,0.000009012567,0.00001447531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001967735,0.00005758622,0.0001639345,0.0001133188,0.00001383823,0.0001302729,0.00003972227,0.0002240466,0.9768023,0.00186715,0.001172938,0.01921816],"study_design_scores_gemma":[0.00008680909,0.000795642,0.0006124044,0.00001788759,0.00004912663,0.0009025151,0.00001482016,0.000635631,0.9407569,0.0002371212,0.05586669,0.00002442478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8312555,0.05895958,0.05802274,0.002248361,0.0007165626,0.0002875938,0.003003189,0.001552955,0.04395356],"genre_scores_gemma":[0.924076,0.02514253,0.02265764,0.00108756,0.0001117926,0.0002384922,0.002836524,0.000102554,0.02374682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532368,"threshold_uncertainty_score":0.005126297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05709729587558364,"score_gpt":0.2999925467153149,"score_spread":0.2428952508397312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}