{"id":"W2157234074","doi":"10.1002/anie.200705435","title":"A New Generation of Specific <i>Trypanosoma cruzi trans</i>‐Sialidase Inhibitors","year":2008,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Trypanosoma cruzi; Substituent; Sialidase; Chemistry; Chagas disease; Substitution (logic); Stereochemistry; Biochemistry; Biology; Enzyme; Virology; Neuraminidase; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00001077392,0.0001406077,0.0001932525,0.0002014845,0.0000915086,0.00002119436,0.0001349878,0.0001069706,0.001792667],"category_scores_gemma":[0.0001030366,0.0001364559,0.0001647088,0.0002524711,0.0001133443,0.0002997596,0.00002422526,0.0001725395,0.00005247846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001480879,"about_ca_system_score_gemma":0.0002073152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000559059,"about_ca_topic_score_gemma":0.000008469499,"domain_scores_codex":[0.9984667,0.00001335378,0.0003892652,0.0002679901,0.0006732699,0.0001894208],"domain_scores_gemma":[0.9989855,0.00003976732,0.0001181311,0.0002381766,0.0004047283,0.0002137245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001228103,0.0001420487,0.0002194755,0.00001222234,0.0000441483,0.00001884076,0.0001546209,0.000002286068,0.7737317,0.0003571304,0.2235015,0.001693234],"study_design_scores_gemma":[0.001285697,0.0001506572,0.02486527,0.00004709277,0.00001534692,0.0002186851,0.00002979593,0.00002811726,0.844458,0.0001389546,0.1286635,0.00009881926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8598924,0.0008541689,0.06878972,0.01834585,0.002864541,0.001008166,0.0005050518,0.0002306869,0.04750938],"genre_scores_gemma":[0.9870155,0.0007589127,0.002332089,0.0002487861,0.005508123,0.0000369519,0.001360348,0.00002206778,0.00271722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1271231,"threshold_uncertainty_score":0.9991198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05709729587558364,"score_gpt":0.2999925467153149,"score_spread":0.2428952508397312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}