{"id":"W2157237731","doi":"10.1093/hmg/ddv252","title":"Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Ontario Institute for Cancer Research; Public Health Ontario; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Institute on Aging; Cancer Research UK; University of Cambridge; National Health and Medical Research Council; Medical Research Council; National Institute for Health and Care Research; National Institutes of Health; U.S. Department of Health and Human Services; National Cancer Institute; British Heart Foundation; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Wellcome Trust; World Health Organization","keywords":"Mendelian randomization; Confounding; Oncology; Odds ratio; Single-nucleotide polymorphism; Lung cancer; Internal medicine; Medicine; Genetic association; Biology; Genetics; Genotype; Genetic variants; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02311112,0.0007327296,0.0009998427,0.0007630683,0.0005934428,0.0008873872,0.001113264,0.001347554,0.001500423],"category_scores_gemma":[0.05574804,0.0004439314,0.001711733,0.001222212,0.0009658962,0.0005310979,0.0006160153,0.0009867902,0.0001834586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005481286,"about_ca_system_score_gemma":0.0007460208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003022778,"about_ca_topic_score_gemma":0.002008426,"domain_scores_codex":[0.9659603,0.02765567,0.001072576,0.003226884,0.001652648,0.0004320093],"domain_scores_gemma":[0.9655479,0.02085383,0.00457576,0.007736579,0.0007649034,0.000521064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01763285,0.0006362057,0.8568122,0.000373589,0.01397042,0.003421212,0.001269364,0.009269212,0.01163615,0.02604148,0.002936214,0.05600106],"study_design_scores_gemma":[0.009079385,0.01049007,0.6630058,0.0003875523,0.01459233,0.01561098,0.0006407084,0.2033205,0.006123303,0.06300387,0.01330137,0.0004442215],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8895088,0.00182035,0.1047547,0.001159758,0.0001734122,0.0004775999,0.0004611558,0.000191456,0.001452837],"genre_scores_gemma":[0.9709347,0.0002539119,0.02758375,0.000317188,0.00006279978,0.0003006394,0.0001843994,0.00003549849,0.0003270732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02311112,"threshold_uncertainty_score":0.1222247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02906344439376389,"score_gpt":0.3080643072403193,"score_spread":0.2790008628465554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}