{"id":"W2157269274","doi":"10.1016/s0968-0896(03)00524-8","title":"Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Prodrug; Stereochemistry; Paclitaxel; Pyrophosphate; Phosphonate; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009079574,0.0001990795,0.000161003,0.0001652264,0.0001254268,0.0001968916,0.0001900977,0.0001735994,0.0009096335],"category_scores_gemma":[0.00009291856,0.0001217007,0.0001209638,0.0001876888,0.0001152277,0.0002129625,0.0001198552,0.0002781142,0.0001811191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002247907,"about_ca_system_score_gemma":0.000245188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003713902,"about_ca_topic_score_gemma":0.0005078483,"domain_scores_codex":[0.9999516,0.000008778889,0.000005461395,0.00001077896,0.00001132108,0.00001202378],"domain_scores_gemma":[0.9999589,0.000006103127,0.00001180713,0.000004670638,0.000005362092,0.00001315772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002503865,0.00004323567,0.00009723759,0.00005492038,0.000005302695,0.0001015575,0.00002379356,0.000524592,0.990582,0.0008697357,0.0000667475,0.007380577],"study_design_scores_gemma":[0.00003321714,0.0004315182,0.0002652245,0.000001597874,0.00001036071,0.00009286102,0.000006217926,0.0004229617,0.9960778,0.00004683612,0.00260796,0.000003420686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986628,0.002127675,0.007030575,0.0001174889,0.00004052176,0.0001051108,0.0002364009,0.00005432467,0.003659809],"genre_scores_gemma":[0.9902858,0.001097618,0.005191956,0.00003520934,0.000007826772,0.00003828472,0.0002949356,0.00001486792,0.003033517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009096335,"threshold_uncertainty_score":0.003042996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386351748503693,"score_gpt":0.241478900678692,"score_spread":0.227615383193655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}