{"id":"W2157269478","doi":"10.1016/j.taap.2007.03.028","title":"Tributyltin induces apoptotic signaling in hepatocytes through pathways involving the endoplasmic reticulum and mitochondria","year":2007,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Marine Biology and Environmental Chemistry","field":"Engineering","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Endoplasmic reticulum; Cell biology; Mitochondrion; Calpain; Thapsigargin; Cytosol; Apoptosis; Calcium signaling; STIM1; Brefeldin A; Biology; Signal transduction; Chemistry; Biochemistry; Golgi apparatus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444707,0.0003704539,0.0002358516,0.0002348004,0.0002583286,0.0003281845,0.0001126836,0.0003080034,0.001487795],"category_scores_gemma":[0.0001450677,0.0001469525,0.0002609412,0.0002684897,0.000227454,0.0002700903,0.0001769509,0.0004532877,0.0002657221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004542644,"about_ca_system_score_gemma":0.000309991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069561,"about_ca_topic_score_gemma":0.002087254,"domain_scores_codex":[0.9998773,0.00002586537,0.00001033458,0.00001472952,0.00002969526,0.00004205749],"domain_scores_gemma":[0.9999108,0.00001444583,0.00002665918,0.00001610863,0.00001469312,0.00001723967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001226241,0.00006133556,0.0004359194,0.00005559038,0.00001508754,0.0002340777,0.00004132277,0.00009476176,0.9946712,0.0002574138,0.0000815774,0.002825472],"study_design_scores_gemma":[0.00005797324,0.0008405737,0.004169921,0.000006039031,0.00002300075,0.0002673371,0.00009297438,0.0004214733,0.9928904,0.0001382913,0.001087435,0.000004665885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957663,0.001171873,0.001172605,0.0001096365,0.00004126759,0.00002247511,0.00007869612,0.00004285282,0.001594297],"genre_scores_gemma":[0.9960432,0.0009079723,0.0006033971,0.00005451966,0.000009290939,0.00001919453,0.0001224381,0.000007423761,0.002232617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487795,"threshold_uncertainty_score":0.004977167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158848607429016,"score_gpt":0.2203590769830303,"score_spread":0.2087705909087401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}