{"id":"W2157366408","doi":"10.1371/journal.pone.0025104","title":"Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Argonne National Laboratory; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; National Natural Science Foundation of China; Stiftelsen för Strategisk Forskning; Chinese Academy of Sciences; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ministry of Science and Technology of the People's Republic of China; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Chromodomain; Heterochromatin protein 1; Histone H3; Biology; Histone methyltransferase; Histone; Biochemistry; Molecular biology; Cell biology; Chemistry; Chromatin; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640757,0.0001505547,0.0002645513,0.0000753721,0.0001066975,0.000005700129,0.0001890483,0.0001204931,0.0004057162],"category_scores_gemma":[0.0000608877,0.0001492995,0.00009481957,0.0001012709,0.00005883358,0.000002993319,0.0001202245,0.00005004613,0.00001896475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004356719,"about_ca_system_score_gemma":0.00001674619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002112133,"about_ca_topic_score_gemma":0.00002219664,"domain_scores_codex":[0.999014,0.00003966306,0.0002446596,0.0003150761,0.0001378217,0.0002488128],"domain_scores_gemma":[0.9993307,0.00001175819,0.0001099541,0.0003384473,0.0001067967,0.0001023231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001918644,0.0001537083,0.000429466,0.00007422268,0.0001650482,0.000001295271,0.0002804976,3.882954e-7,0.9981257,0.0001135847,0.0002401478,0.0002240833],"study_design_scores_gemma":[0.0004871711,0.0007282576,0.0009616318,0.0000473504,0.00006057248,0.000001772534,0.00002427324,0.00000813794,0.9969257,0.0001251888,0.0004390735,0.0001908916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997535,0.000322996,0.0001146421,0.00003943166,0.00003760719,0.0004758914,0.0001447022,0.00001719199,0.001312471],"genre_scores_gemma":[0.9860003,0.00002034907,0.01201743,0.00004427366,0.0001500212,0.00005538141,0.0002087013,0.000034506,0.001469015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01190279,"threshold_uncertainty_score":0.6088256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0952143179902603,"score_gpt":0.2727984529418752,"score_spread":0.1775841349516148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}