{"id":"W2157366408","doi":"10.1371/journal.pone.0025104","title":"Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Argonne National Laboratory; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; National Natural Science Foundation of China; Stiftelsen för Strategisk Forskning; Chinese Academy of Sciences; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ministry of Science and Technology of the People's Republic of China; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Chromodomain; Heterochromatin protein 1; Histone H3; Biology; Histone methyltransferase; Histone; Biochemistry; Molecular biology; Cell biology; Chemistry; Chromatin; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004612194,0.0002348952,0.0001660457,0.00007333899,0.000202379,0.0001636269,0.0003927074,0.0002929374,0.00167036],"category_scores_gemma":[0.0001305322,0.0001060135,0.0001664735,0.00007198228,0.0001864271,0.0001173138,0.0002035187,0.0003773551,0.0003650142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004456069,"about_ca_system_score_gemma":0.0002311961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291676,"about_ca_topic_score_gemma":0.001367548,"domain_scores_codex":[0.9999563,0.000003075177,0.000001809364,0.0000140699,0.000015339,0.000009396867],"domain_scores_gemma":[0.9999456,0.000007431073,0.00001656989,0.000003634785,0.000007028919,0.00001967144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004263512,0.00007968943,0.003415451,0.00019386,0.00003572132,0.001465254,0.00007861267,0.001726456,0.9871493,0.00101168,0.000694032,0.003723569],"study_design_scores_gemma":[0.0002425605,0.0004625917,0.06741179,0.00003465413,0.00007967331,0.004261776,0.0002241778,0.04346126,0.8715624,0.001400311,0.01081415,0.00004460398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949266,0.0007134739,0.002538655,0.0001113309,0.00003187274,0.00002325535,0.0002205476,0.0001180117,0.001316299],"genre_scores_gemma":[0.9977903,0.0001334122,0.001141577,0.00004271842,0.000005184597,0.00001025234,0.0003053834,0.000007534657,0.0005635727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167036,"threshold_uncertainty_score":0.005587935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0952143179902603,"score_gpt":0.2727984529418752,"score_spread":0.1775841349516148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}