{"id":"W2157421521","doi":"10.1126/science.1176495","title":"A Global Protein Kinase and Phosphatase Interaction Network in Yeast","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":694,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Kinome; Phosphorylation; Phosphatase; Kinase; Protein phosphorylation; Biochemistry; Yeast; Cell biology; Biology; Chemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002815452,0.00004779929,0.00003391571,0.00001882896,0.00006450921,0.00004379605,0.0001531155,0.00003501989,0.00001235976],"category_scores_gemma":[0.00009573221,0.00004243722,0.000009017037,0.0002557967,0.00025189,0.000005738845,0.0001661355,0.00007576582,0.000008028803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007449228,"about_ca_system_score_gemma":0.00009942867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003873625,"about_ca_topic_score_gemma":0.0004594588,"domain_scores_codex":[0.9993656,0.00001090723,0.00005778768,0.0002331491,0.0001232306,0.0002093058],"domain_scores_gemma":[0.999709,0.000001407515,0.00001420679,0.0001479755,0.00003877924,0.00008867288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003343986,0.00001851289,0.01141714,0.000003098532,5.116195e-7,0.000003023867,0.000007375709,0.00003364855,0.9789093,0.0002094453,0.00007464374,0.009289844],"study_design_scores_gemma":[0.0004234134,0.000211587,0.1048412,0.00002112956,0.000001262558,0.00003226267,0.00004012304,0.001103596,0.8679948,0.0006005013,0.02455495,0.0001751744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985593,0.0002128846,0.00004589881,0.00007632099,0.0001445195,0.0001082568,0.000008327787,0.00000251131,0.0008419552],"genre_scores_gemma":[0.9989135,0.00001207575,0.0008163444,0.00004209083,0.00009573232,0.00001128914,0.00000472517,0.000002113056,0.0001021804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1109145,"threshold_uncertainty_score":0.173054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007564198984088524,"score_gpt":0.2911190644347816,"score_spread":0.2835548654506931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}