{"id":"W2157425818","doi":"10.1242/dmm.007310","title":"The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents","year":2011,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; Institute for Marine Biosciences","funders":"Dalhousie University","keywords":"Zebrafish; Embryo; Biology; Cancer cell; Apoptosis; Cytotoxicity; Programmed cell death; In vivo; Peptide; Cancer; In vitro; Toxicity; Cell biology; Molecular biology; Pharmacology; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002260223,0.000315665,0.0003136392,0.0000625513,0.0009391691,0.0001075046,0.0002621691,0.0001401705,0.0001846146],"category_scores_gemma":[0.00005866654,0.0002498866,0.0002075361,0.00005488477,0.0001803538,0.000398798,0.0001981551,0.0001832997,0.00005521223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001739322,"about_ca_system_score_gemma":0.00007299175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001762302,"about_ca_topic_score_gemma":0.000007056029,"domain_scores_codex":[0.9984719,0.00009758931,0.0002825306,0.0004880104,0.00006116217,0.0005988705],"domain_scores_gemma":[0.9992571,0.00009612633,0.0001763176,0.0002991932,0.00008585768,0.00008541296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001470982,0.0001304159,0.0001304514,0.00007121936,0.0003907354,0.00002031224,0.001825169,0.00001591929,0.940687,0.05035368,0.001173186,0.003730938],"study_design_scores_gemma":[0.004336522,0.0005990404,0.00696399,0.0004534433,0.0007488641,0.00007340772,0.003294728,0.00187941,0.9074537,0.06797536,0.004574048,0.001647477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843404,0.0008562558,0.01272209,0.0003018511,0.0003838181,0.0006884171,0.0003783054,0.0001173435,0.000211511],"genre_scores_gemma":[0.9942146,0.0004752024,0.000534354,0.001728594,0.00005303463,0.0001977196,0.00008374578,0.00006085897,0.002651905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03323328,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03836791187870757,"score_gpt":0.2501168909205945,"score_spread":0.2117489790418869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}