{"id":"W2157445694","doi":"10.1371/journal.pone.0078671","title":"A ΔclpB Mutant of Francisella tularensis Subspecies holarctica Strain, FSC200, Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Francisella tularensis; Tularemia; Virulence; Attenuated vaccine; Biology; Virology; Microbiology; Francisella; CLPB; Vaccination; Mutant; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004672674,0.0003660203,0.0008056649,0.0002201852,0.00006392284,0.00002513555,0.0003717018,0.0004235377,0.0001956977],"category_scores_gemma":[0.000485341,0.000349236,0.000233253,0.0002574068,0.0002193002,0.0000212043,0.0002553251,0.0003311494,0.00002006837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005515636,"about_ca_system_score_gemma":0.0001497531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003220936,"about_ca_topic_score_gemma":0.0002073587,"domain_scores_codex":[0.9972876,0.0002038283,0.0006425797,0.0006703444,0.0006217911,0.0005738059],"domain_scores_gemma":[0.9976813,0.00007433718,0.0002286937,0.0008635661,0.0009458761,0.0002062228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004701194,0.001303271,0.002934906,0.0004394564,0.0004346576,0.000008106891,0.001279959,0.00003998834,0.991657,0.00002271023,0.0000600003,0.001349784],"study_design_scores_gemma":[0.001694577,0.0009272372,0.008483273,0.000218687,0.00008187691,0.000001431648,0.0003082041,0.002407328,0.9853051,0.0001855992,0.0000269574,0.0003597371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956803,0.001907557,0.0001834126,0.0002043397,0.00001800542,0.001223581,0.0005575679,0.00001514812,0.0002101147],"genre_scores_gemma":[0.9973414,0.001005362,0.0009816372,0.0001506567,0.0001024258,0.0001862487,0.00006058841,0.00007053152,0.0001011674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006351948,"threshold_uncertainty_score":0.999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281495813238026,"score_gpt":0.2435263143392555,"score_spread":0.2107113562068753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}