{"id":"W2157445694","doi":"10.1371/journal.pone.0078671","title":"A ΔclpB Mutant of Francisella tularensis Subspecies holarctica Strain, FSC200, Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Francisella tularensis; Tularemia; Virulence; Attenuated vaccine; Biology; Virology; Microbiology; Francisella; CLPB; Vaccination; Mutant; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114794,0.0003337029,0.0002473156,0.0002105008,0.0001060481,0.0001330657,0.0002054,0.0003203081,0.0007155344],"category_scores_gemma":[0.00007423429,0.0001004629,0.0001999942,0.0001066506,0.0001902088,0.000162084,0.0001022403,0.0005821369,0.0001165523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182391,"about_ca_system_score_gemma":0.0002058649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001652912,"about_ca_topic_score_gemma":0.001742326,"domain_scores_codex":[0.9998831,0.00001261075,0.0000146639,0.00002801879,0.00003060302,0.00003097921],"domain_scores_gemma":[0.9999255,0.000009945551,0.00002493278,0.000005463602,0.000010065,0.0000241268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000246706,0.0000816538,0.0002119316,0.00003765147,0.000004317904,0.00002696959,0.000009963885,0.0000686545,0.9983943,0.00002743466,0.00004754583,0.0008428543],"study_design_scores_gemma":[0.0000503417,0.002386002,0.006463501,0.00001350247,0.00003222443,0.0002699421,0.00004379874,0.001026688,0.9879929,0.0000281594,0.001684348,0.00000855376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983416,0.0003853145,0.0005827392,0.00006096816,0.000022157,0.00001385131,0.0002493875,0.00003338512,0.000310642],"genre_scores_gemma":[0.9963638,0.0003151248,0.0009185355,0.00006094106,0.000009020709,0.00002872964,0.0007954275,0.000009505967,0.001498924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001652912,"threshold_uncertainty_score":0.003286541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281495813238026,"score_gpt":0.2435263143392555,"score_spread":0.2107113562068753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}