{"id":"W2157479134","doi":"10.1074/jbc.c800179200","title":"Control of MAPK Specificity by Feedback Phosphorylation of Shared Adaptor Protein Ste50","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Cell biology; MAPK/ERK pathway; Biology; Phosphorylation; Mitogen-activated protein kinase; Signal transduction; Signal transducing adaptor protein; Kinase; Protein kinase A; Osmotic shock; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000221853,0.0003665939,0.0001668835,0.0001832911,0.0001390121,0.0003905848,0.0002822974,0.0001636773,0.001985284],"category_scores_gemma":[0.0002811138,0.0001655222,0.0001397366,0.00009842961,0.0002275401,0.0002809648,0.0005389354,0.0003492583,0.0005573165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003691968,"about_ca_system_score_gemma":0.0001386917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002024938,"about_ca_topic_score_gemma":0.0004747893,"domain_scores_codex":[0.9998018,0.00002642851,0.00001449799,0.00005603738,0.00004138531,0.00005978754],"domain_scores_gemma":[0.9997848,0.00005135899,0.00005274562,0.00002866888,0.00003238411,0.00004995837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009848586,0.00001165532,0.0002239113,0.00001393294,0.000002073752,0.0000293908,0.000007958285,0.0001218648,0.9980277,0.0001825622,0.00002702229,0.001253366],"study_design_scores_gemma":[0.00001910633,0.00007264683,0.00318261,0.000003561671,0.000006898655,0.0001384546,0.00001923204,0.005722001,0.9898191,0.0002351745,0.0007739814,0.000007213557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937351,0.0004485274,0.003873307,0.00005025343,0.00001920936,0.00001268168,0.00008131455,0.0001409876,0.001638534],"genre_scores_gemma":[0.9985009,0.0001091525,0.00079144,0.00001216575,0.000003034967,0.000008424284,0.00004924803,0.00001562013,0.0005100485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985284,"threshold_uncertainty_score":0.006641448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02506003006531034,"score_gpt":0.2457869677449183,"score_spread":0.2207269376796079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}