{"id":"W2157482215","doi":"10.1186/s13041-014-0054-1","title":"The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid","year":2014,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"Endosome; Amyloid precursor protein; Alpha secretase; Cell biology; Golgi apparatus; Lysosome; Amyloid precursor protein secretase; Intracellular; Green fluorescent protein; P3 peptide; Brefeldin A; Amyloid beta; Biology; Chemistry; Biochemistry; Alzheimer's disease; Endoplasmic reticulum; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689882,0.0003720832,0.0002868935,0.0002740836,0.0003317925,0.0008017015,0.0002197834,0.0003992021,0.001672363],"category_scores_gemma":[0.0001211551,0.0001186959,0.0003310235,0.0003292095,0.0002154258,0.000425954,0.0003675538,0.0004487541,0.001976976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005526221,"about_ca_system_score_gemma":0.0004788337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112467,"about_ca_topic_score_gemma":0.0005808774,"domain_scores_codex":[0.999909,0.000007431878,0.000008922746,0.00002559162,0.00003135447,0.00001758026],"domain_scores_gemma":[0.9999019,0.000004756232,0.00002890632,0.000006704688,0.00003595601,0.00002162653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001614742,0.00002598603,0.001798144,0.0002473621,0.00002483102,0.0005533218,0.00005576466,0.0001071716,0.9798221,0.0007308697,0.0005192123,0.01595378],"study_design_scores_gemma":[0.00003397148,0.0003506494,0.02184621,0.0001433306,0.00006505337,0.00417249,0.0002050543,0.0009561265,0.9049512,0.001032626,0.06621626,0.0000270226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9038211,0.04844579,0.02910776,0.0006370028,0.0003780685,0.0002057337,0.002122971,0.0009691707,0.01431235],"genre_scores_gemma":[0.9474541,0.02280402,0.01297308,0.0002288774,0.00006644464,0.00008213508,0.001976353,0.00007749785,0.01433751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672363,"threshold_uncertainty_score":0.005594611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226174961193721,"score_gpt":0.2748565524693246,"score_spread":0.2625948028573874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}