{"id":"W2157482215","doi":"10.1186/s13041-014-0054-1","title":"The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid","year":2014,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"Endosome; Amyloid precursor protein; Alpha secretase; Cell biology; Golgi apparatus; Lysosome; Amyloid precursor protein secretase; Intracellular; Green fluorescent protein; P3 peptide; Brefeldin A; Amyloid beta; Biology; Chemistry; Biochemistry; Alzheimer's disease; Endoplasmic reticulum; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005102631,0.0003378516,0.0003409454,0.00004216721,0.0004921932,0.0001936014,0.0004456351,0.0001138005,0.0001550251],"category_scores_gemma":[0.0001790369,0.0001612551,0.0001934839,0.0003802226,0.000250559,0.00008027983,0.0000757874,0.0003259877,0.0002016245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004157698,"about_ca_system_score_gemma":0.0002198787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003760878,"about_ca_topic_score_gemma":0.0002691233,"domain_scores_codex":[0.997422,0.0003282435,0.0003082062,0.0005874052,0.0007919322,0.0005622274],"domain_scores_gemma":[0.998081,0.0002380752,0.00008923296,0.001008385,0.0001500436,0.000433282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007797732,0.002611535,0.01301584,0.0009259987,0.0491082,0.0008653063,0.04111091,0.00001855468,0.3561423,0.002343883,0.3983864,0.1276733],"study_design_scores_gemma":[0.01382903,0.002718277,0.03421972,0.0009075817,0.003592128,0.00004393182,0.002663368,0.001008034,0.3954001,0.007833564,0.536434,0.001350268],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.724369,0.02133632,0.0006742332,0.2481017,0.00003116932,0.00412505,0.0001456186,0.00006632502,0.001150565],"genre_scores_gemma":[0.9842338,0.000114929,0.0002134454,0.0137332,0.0001129738,0.000776735,0.0000880931,0.00006131914,0.0006655299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2598647,"threshold_uncertainty_score":0.6575793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226174961193721,"score_gpt":0.2748565524693246,"score_spread":0.2625948028573874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}