{"id":"W2157516595","doi":"10.1128/iai.01070-08","title":"Involvement of SOCS3 in Regulation of CD11c <sup>+</sup> Dendritic Cell-Derived Osteoclastogenesis and Severe Alveolar Bone Loss","year":2009,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Dental and Craniofacial Research; National Institutes of Health","keywords":"RANKL; Bone resorption; SOCS3; CD11c; Biology; Inflammation; Cell biology; Nod; Immunology; Cancer research; Dendritic cell; Osteoclast; Cytokine; Signal transduction; Immune system; In vivo; Endocrinology; Receptor; STAT3; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622617,0.00009026677,0.0001587021,0.00006490428,0.0000486844,0.000007608783,0.00002815378,0.00008646926,0.00001474081],"category_scores_gemma":[0.00004475222,0.00009063641,0.00004606726,0.00008141425,0.00007547065,0.00001102529,0.00003980342,0.00004720575,3.75007e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005387472,"about_ca_system_score_gemma":0.00002643293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295196,"about_ca_topic_score_gemma":0.00004616244,"domain_scores_codex":[0.9993658,0.0001206965,0.000230775,0.0001283015,0.00006788187,0.00008655206],"domain_scores_gemma":[0.9996155,0.00001064434,0.00009077629,0.0001694777,0.00007400936,0.00003962977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001261727,0.0002310479,0.09272935,0.00008116263,0.00001308015,3.714971e-7,0.0001958777,0.0001827206,0.9021891,0.00003560811,0.0000411505,0.004174399],"study_design_scores_gemma":[0.0009307765,0.0002012545,0.6238665,0.00001933432,0.00002513468,0.000006238429,0.0001457913,0.00007282764,0.3741399,0.0001634522,0.0003436435,0.00008513335],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977219,0.001815691,0.0001048719,0.0000263876,0.00002090014,0.0001100296,0.00001412194,0.00000402335,0.0001820984],"genre_scores_gemma":[0.9987992,0.0009356719,0.00007692869,0.00005874612,0.00001840439,0.000003445548,0.00005724235,0.000004614285,0.00004572239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5311372,"threshold_uncertainty_score":0.3696046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007378111567422724,"score_gpt":0.2200436793262135,"score_spread":0.2126655677587908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}