{"id":"W2157516595","doi":"10.1128/iai.01070-08","title":"Involvement of SOCS3 in Regulation of CD11c <sup>+</sup> Dendritic Cell-Derived Osteoclastogenesis and Severe Alveolar Bone Loss","year":2009,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Dental and Craniofacial Research; National Institutes of Health","keywords":"RANKL; Bone resorption; SOCS3; CD11c; Biology; Inflammation; Cell biology; Nod; Immunology; Cancer research; Dendritic cell; Osteoclast; Cytokine; Signal transduction; Immune system; In vivo; Endocrinology; Receptor; STAT3; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220847,0.0003835897,0.0002564907,0.0002766992,0.0001704097,0.0003478296,0.0001141001,0.0002672325,0.001108848],"category_scores_gemma":[0.0001447514,0.0001185389,0.0004994574,0.0001494521,0.0004276215,0.0001747575,0.0002738535,0.0004484755,0.0002705664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003930923,"about_ca_system_score_gemma":0.0004061772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008410095,"about_ca_topic_score_gemma":0.001009384,"domain_scores_codex":[0.999779,0.00003556986,0.00003141656,0.0000275477,0.0000515596,0.00007473579],"domain_scores_gemma":[0.9998094,0.00001393713,0.00008889587,0.0000140709,0.00001742319,0.00005621568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003860171,0.00001655486,0.001159827,0.00006363199,0.00000696058,0.0001739271,0.00001963314,0.00007340024,0.9969818,0.0001288078,0.00004242695,0.0009469333],"study_design_scores_gemma":[0.0001320019,0.0006324493,0.1183328,0.00003341946,0.0000711151,0.002897282,0.0001877178,0.002788959,0.8706345,0.0005212773,0.003735685,0.00003278686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942264,0.002274006,0.00188047,0.0001063865,0.0000237175,0.00002155277,0.0007110058,0.00009386888,0.0006626752],"genre_scores_gemma":[0.9977461,0.0004700183,0.0008121327,0.00007303592,0.000007907514,0.0000279105,0.0003903839,0.00001170742,0.0004609444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108848,"threshold_uncertainty_score":0.003709495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007378111567422724,"score_gpt":0.2200436793262135,"score_spread":0.2126655677587908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}