{"id":"W2157531288","doi":"10.4155/bio.13.104","title":"Antibody–Drug Conjugate Drug Development: Where are The Challenges?","year":2013,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Intertek (Canada)","funders":"","keywords":"Drug development; Antibody-drug conjugate; Drug; Library science; Medicine; Pharmacology; Monoclonal antibody; Antibody; Computer science; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003950242,0.0002399454,0.0004554398,0.0001777061,0.0003208896,0.00007566658,0.0003157803,0.00005979304,0.002315506],"category_scores_gemma":[0.00004707294,0.0001337694,0.0002801884,0.0004185622,0.0002013296,0.0001030818,0.0001587694,0.0003007321,0.002843166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005117218,"about_ca_system_score_gemma":0.0001078099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009293515,"about_ca_topic_score_gemma":0.0005543652,"domain_scores_codex":[0.9979513,0.0001180718,0.0003726882,0.0003888203,0.0006889582,0.0004801747],"domain_scores_gemma":[0.998659,0.00014705,0.0001296982,0.0004903216,0.0003044832,0.0002694538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004399129,0.001274716,0.5830125,0.001834192,0.009813132,0.000577439,0.009890273,0.00001547271,0.01061577,0.0038832,0.05388078,0.3247626],"study_design_scores_gemma":[0.0007480918,0.0000372828,0.2852013,0.0002501277,0.0003809104,0.0000454473,0.004208953,0.0007973431,0.002189469,0.0002743797,0.7054468,0.0004198186],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7798595,0.07786302,0.0000268462,0.1093948,0.0001460717,0.0006877457,0.00001643487,0.0001147327,0.03189082],"genre_scores_gemma":[0.9462922,0.01029609,0.0004716923,0.0008168879,0.0002657675,0.00006103496,0.00006465067,0.00002701754,0.04170468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.651566,"threshold_uncertainty_score":0.9985965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02865387944286323,"score_gpt":0.2979153985429724,"score_spread":0.2692615191001092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}