{"id":"W2157533742","doi":"10.1086/497610","title":"Pharmacogenetics of Long‐Term Responses to Antiretroviral Regimens Containing Efavirenz and/or Nelfinavir: An Adult AIDS Clinical Trials Group Study","year":2005,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; ACT Government; School of Medicine, Vanderbilt University; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases","keywords":"Efavirenz; Nelfinavir; CYP2B6; CYP2C19; Medicine; Population; Pharmacology; Pharmacogenetics; Abacavir; Internal medicine; Virology; Biology; Viral load; Genotype; Virus; CYP3A4; Genetics; Cytochrome P450; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0077763,0.0007999258,0.00124016,0.0002885652,0.0003921956,0.0007348155,0.0006608809,0.001144441,0.001990444],"category_scores_gemma":[0.007471633,0.0004053168,0.00119342,0.0007949386,0.0004734096,0.000513515,0.0003394853,0.0009198266,0.0003291718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003463996,"about_ca_system_score_gemma":0.0005512037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004715424,"about_ca_topic_score_gemma":0.0007260782,"domain_scores_codex":[0.9948607,0.003903794,0.0003328816,0.0004977867,0.0002571681,0.0001476234],"domain_scores_gemma":[0.9935163,0.002410708,0.002206419,0.0009194742,0.0003987726,0.0005481955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3831321,0.003705145,0.5593317,0.0005773049,0.01803348,0.0003974159,0.0002714599,0.001585063,0.004735823,0.000257048,0.001329038,0.0266445],"study_design_scores_gemma":[0.1059559,0.05097384,0.8241321,0.0001402348,0.01055619,0.0008980791,0.0001259224,0.002462999,0.001157573,0.0005247179,0.003001892,0.00007057582],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970728,0.001355961,0.0003064973,0.0001162971,0.00001638453,0.0002527845,0.0005028889,0.00000691285,0.0003694211],"genre_scores_gemma":[0.9971303,0.0003892776,0.0005799219,0.0001773351,0.00005444898,0.0004447196,0.0008372533,0.000004634873,0.0003821472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0077763,"threshold_uncertainty_score":0.04112554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07383009193538165,"score_gpt":0.4336922300749886,"score_spread":0.359862138139607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}