{"id":"W2157536177","doi":"10.1371/journal.pgen.1004768","title":"SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Institut National de la Santé et de la Recherche Médicale; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Reprogramming; Thymocyte; Cell biology; Transcription factor; Cellular differentiation; Stem cell; T cell; Immunology; Genetics; Cell; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008614823,0.0002671403,0.000178087,0.000196259,0.0000906382,0.0003039353,0.0001421828,0.0002319835,0.0008446714],"category_scores_gemma":[0.00007560958,0.0001060685,0.0001827598,0.0001305721,0.0001796146,0.0001603509,0.0002969228,0.0003692929,0.0004481152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391582,"about_ca_system_score_gemma":0.0001879629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003767758,"about_ca_topic_score_gemma":0.0007114036,"domain_scores_codex":[0.9998691,0.00001986243,0.00001418231,0.00003000628,0.00003533716,0.00003151735],"domain_scores_gemma":[0.9998918,0.00001545795,0.0000299777,0.0000164742,0.000007226741,0.00003911821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003430655,0.000008433618,0.0001658907,0.00001315498,0.00000176607,0.00002476524,0.000008028456,0.00002863324,0.998904,0.00006174715,0.00001417356,0.0007350115],"study_design_scores_gemma":[0.000005371889,0.00008220455,0.001917318,0.000002550556,0.000005791029,0.0001612271,0.00001723913,0.0003525247,0.9954022,0.00002713987,0.002024741,0.000001766022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936195,0.001349798,0.002585089,0.00008828469,0.00001565581,0.00001940512,0.0002943575,0.0001063759,0.001921518],"genre_scores_gemma":[0.9940767,0.0006431754,0.001651552,0.00005085329,0.000005194961,0.0000219423,0.0004197516,0.00002441453,0.003106331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008446714,"threshold_uncertainty_score":0.002825677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441979083276302,"score_gpt":0.2638890735830841,"score_spread":0.249469282750321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}