{"id":"W2157536177","doi":"10.1371/journal.pgen.1004768","title":"SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Institut National de la Santé et de la Recherche Médicale; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Reprogramming; Thymocyte; Cell biology; Transcription factor; Cellular differentiation; Stem cell; T cell; Immunology; Genetics; Cell; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002673043,0.000196973,0.0003080225,0.0001076432,0.0001090563,0.00006445105,0.0001602648,0.0001554124,0.00004073948],"category_scores_gemma":[0.0002589501,0.0001697883,0.00005303668,0.0001991655,0.0001382783,0.00003571946,0.0002284444,0.0002172996,0.0001335059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001929091,"about_ca_system_score_gemma":0.0002171405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002179452,"about_ca_topic_score_gemma":0.000006775114,"domain_scores_codex":[0.9982468,0.000067017,0.0002678805,0.0004471085,0.0005287315,0.0004424712],"domain_scores_gemma":[0.998573,0.0002602051,0.00005687263,0.0006032225,0.0001671503,0.0003395702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002839978,0.001152739,0.04905925,0.001698584,0.0007715987,0.000175762,0.005116676,0.00009542383,0.8254083,0.0002443371,0.006134416,0.1098589],"study_design_scores_gemma":[0.003664859,0.00123704,0.001777288,0.0002238153,0.0004237277,0.0001029123,0.0001944041,0.1282458,0.832091,0.000530779,0.03109015,0.0004182815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943016,0.0009905485,0.0006354144,0.0005408182,0.0001074617,0.0004518123,0.000002100771,0.0001972921,0.002773011],"genre_scores_gemma":[0.9594451,0.0004564877,0.03861847,0.0004762051,0.000531304,0.00002816851,0.0000099616,0.00006246795,0.0003718235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1281504,"threshold_uncertainty_score":0.6923764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441979083276302,"score_gpt":0.2638890735830841,"score_spread":0.249469282750321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}