{"id":"W2157562973","doi":"10.1073/pnas.1936664100","title":"β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":511,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Arrestin; G protein-coupled receptor; Gs alpha subunit; Adenylyl cyclase; Agonist; Cell biology; G protein; Receptor; Inverse agonist; Signal transduction; Protein kinase A; MAPK/ERK pathway; Heterotrimeric G protein; Gi alpha subunit; Biology; G protein-coupled receptor kinase; HEK 293 cells; Chemistry; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021045,0.0002585634,0.0001918273,0.0001953844,0.0001198324,0.0003773374,0.0001827959,0.0001753974,0.0009987539],"category_scores_gemma":[0.00008064631,0.0001407778,0.0003101447,0.00008036511,0.0001200533,0.0002151731,0.0001197593,0.000588914,0.0004518929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002009994,"about_ca_system_score_gemma":0.00007291591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001346753,"about_ca_topic_score_gemma":0.0002143156,"domain_scores_codex":[0.9999225,0.00001136718,0.000006516303,0.00001661719,0.00002201478,0.00002083189],"domain_scores_gemma":[0.9999655,0.000006115064,0.00001025285,0.000004099833,0.000003894738,0.00001001012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006177973,0.000006436263,0.00004467737,0.000009941716,0.000001582342,0.00002111486,0.000008665193,0.00001567567,0.9993396,0.0001450201,0.000010184,0.0003352411],"study_design_scores_gemma":[0.00003104084,0.0001981462,0.009090558,0.0000130885,0.00001814537,0.0007313418,0.00005944817,0.002112013,0.9831887,0.0002151267,0.004330033,0.00001241265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938591,0.00106789,0.002756572,0.00007715572,0.00001343506,0.00001662799,0.0002137925,0.00003082592,0.001964677],"genre_scores_gemma":[0.9921179,0.001421,0.002771586,0.00008497418,0.00001733767,0.00004347862,0.0007407069,0.0000295688,0.002773406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009987539,"threshold_uncertainty_score":0.003341198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02378411376004193,"score_gpt":0.2770343624444765,"score_spread":0.2532502486844346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}