{"id":"W2157620455","doi":"10.4049/jimmunol.167.3.1313","title":"4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy","year":2001,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CD28; Cytotoxic T cell; CD8; Interleukin 21; Biology; T cell; IL-2 receptor; Cytokine; Molecular biology; Natural killer T cell; Cell biology; Antigen; Immunology; Immune system; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333288,0.0003731453,0.0002473333,0.0002572317,0.0001252726,0.0002871209,0.0001487475,0.000219248,0.001463527],"category_scores_gemma":[0.000148959,0.000109697,0.0001431992,0.000111052,0.0001501692,0.0001126724,0.0001973129,0.0004520855,0.000603207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000307178,"about_ca_system_score_gemma":0.0001949568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001958924,"about_ca_topic_score_gemma":0.0003191333,"domain_scores_codex":[0.999724,0.00005235459,0.00001838804,0.00003223688,0.00006024757,0.0001127212],"domain_scores_gemma":[0.9998618,0.00003268965,0.00002799456,0.00001722073,0.00001513351,0.00004510643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001475766,0.00004663858,0.0001332952,0.00001923054,0.000002006903,0.00003800802,0.000008860981,0.00006468076,0.9979841,0.00003419308,0.00002635758,0.001495136],"study_design_scores_gemma":[0.0001006324,0.000837072,0.00424546,0.000007951487,0.00001433156,0.0002720926,0.0000257725,0.001118671,0.9905497,0.00008516396,0.002738863,0.000004284435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964936,0.0008244331,0.0007348408,0.00005030377,0.0000171366,0.00001484725,0.00005213184,0.00006178824,0.001750905],"genre_scores_gemma":[0.9953755,0.0003339055,0.001154441,0.00004505842,0.00002652678,0.0000288185,0.0002111019,0.00001698637,0.002807609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001463527,"threshold_uncertainty_score":0.004895985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007769988992929988,"score_gpt":0.2187419373106236,"score_spread":0.2109719483176936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}