{"id":"W2157635452","doi":"10.1139/o06-199","title":"Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1)This paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.","year":2006,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Flippase; ATP-binding cassette transporter; Efflux; Transporter; Lipid bilayer; Phospholipid scramblase; Biochemistry; P-glycoprotein; Biology; ATP hydrolysis; ATPase; Translocase; Function (biology); Membrane transport protein; Cell biology; Transport protein; Multiple drug resistance; Phospholipid; Membrane; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006095678,0.0004962279,0.0009725838,0.000813672,0.000485259,0.002130438,0.0004845139,0.002197811,0.002423535],"category_scores_gemma":[0.0006586494,0.0002086894,0.0003476962,0.001347789,0.0008758323,0.002846163,0.0007668242,0.00283079,0.00175761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008511186,"about_ca_system_score_gemma":0.000982973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006012165,"about_ca_topic_score_gemma":0.0009041138,"domain_scores_codex":[0.9997512,0.00004621596,0.00002182432,0.00004920259,0.00009475277,0.00003681317],"domain_scores_gemma":[0.9997649,0.00007305873,0.00003554193,0.000008888728,0.00006887362,0.00004885324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002308758,0.00008172921,0.0007413632,0.01127416,0.00008456824,0.0009807434,0.0005413588,0.0005319756,0.06572168,0.03609427,0.1963678,0.6873495],"study_design_scores_gemma":[0.000007775008,0.00006548279,0.0006190153,0.0004572517,0.00002845326,0.001021909,0.0001174533,0.000125832,0.003529673,0.005159851,0.9888523,0.00001509823],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.001172985,0.9824162,0.0008421597,0.009929684,0.003885052,0.000004892635,0.0000476931,0.00002552674,0.001675883],"genre_scores_gemma":[0.006552184,0.9813821,0.0006196009,0.003173761,0.00550418,0.000008037792,0.00009410876,0.00001540488,0.002650649],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002423535,"threshold_uncertainty_score":0.008107483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002900910742883982,"score_gpt":0.1899317249398703,"score_spread":0.1870308141969863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}