{"id":"W2157659414","doi":"10.1021/jo502150v","title":"Preparation of 1,7- and 3,9-Dideazapurines from 2-Amino-3-iodo- and 3-Amino-4-iodopyridines and Activated Acetylenes by Conjugate Addition and Copper-Catalyzed Intramolecular Arylation","year":2014,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Conjugate; Intramolecular force; Chemistry; Catalysis; Ketone; Copper; Solvent; Amino acid; Combinatorial chemistry; Sulfone; Medicinal chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004648211,0.000200384,0.000331866,0.00002906611,0.0001077722,0.00005317672,0.00009910602,0.0001499808,0.0003619723],"category_scores_gemma":[0.0006463042,0.0001647086,0.00002983025,0.00009548697,0.0002563167,0.000222258,0.00008967835,0.00018233,3.945612e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003279718,"about_ca_system_score_gemma":0.00004367495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003052887,"about_ca_topic_score_gemma":0.00000375068,"domain_scores_codex":[0.9988704,0.00006158566,0.0005021026,0.000206709,0.0002449333,0.0001142675],"domain_scores_gemma":[0.9982682,0.0005683485,0.0006472885,0.0002066943,0.0002035882,0.0001059182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002323469,0.00002880762,0.001445213,0.0001864264,0.0001037036,7.265455e-7,0.0003208377,0.000006937082,0.9953693,0.000006454913,0.0003805376,0.001918775],"study_design_scores_gemma":[0.001403339,0.00003326116,0.001591987,0.0001285758,0.0002468432,0.0003065685,0.0003956187,0.0009773086,0.9937499,0.0004491063,0.0005544364,0.0001631197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962397,0.001548281,0.001580121,0.0003399264,0.0000315647,0.00005824675,0.00006754071,0.00001687758,0.0001177154],"genre_scores_gemma":[0.9979484,0.001047304,0.0004722969,0.00002731819,0.0001835944,0.000001641856,0.0001728555,0.00002390222,0.000122675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755655,"threshold_uncertainty_score":0.6716622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008617316021544277,"score_gpt":0.2490689365861764,"score_spread":0.2404516205646322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}