{"id":"W2157673714","doi":"10.1136/annrheumdis-2013-205007","title":"Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness","year":2014,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Reumatikerförbundet; Vetenskapsrådet; Canadian Institutes of Health Research; Stockholms Läns Landsting; French Muscular Dystrophy Association; Magnus Bergvalls Stiftelse; Åke Wiberg Stiftelse; Muscular Dystrophy Association; Karolinska Institutet; Stiftelsen för Strategisk Forskning","keywords":"Medicine; Muscle weakness; Actin; Arthritis; Weakness; Biophysics; Anatomy; Internal medicine; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009676916,0.00007832527,0.0001148126,0.00001769058,0.0001226632,0.000009695923,0.0001406561,0.00003809714,0.00001995008],"category_scores_gemma":[0.0004106588,0.0000505689,0.0001002352,0.00007833404,0.000151754,0.000005475012,0.00007275111,0.00002916973,0.000001156384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002355549,"about_ca_system_score_gemma":0.00003919191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003080076,"about_ca_topic_score_gemma":0.00001253007,"domain_scores_codex":[0.9993359,0.0001424113,0.000191687,0.0001194777,0.0001252492,0.00008522713],"domain_scores_gemma":[0.9992279,0.00004736797,0.0002034884,0.0003493742,0.000126189,0.00004564522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005244364,0.001647818,0.007069517,0.0007760724,0.0006284378,1.952394e-7,0.00151907,0.005175977,0.5203242,0.02361524,0.03196611,0.4067529],"study_design_scores_gemma":[0.001253772,0.0002059736,0.7834996,0.0003805201,0.000084729,0.000004232221,0.001040847,0.009429078,0.1929962,0.00833847,0.002485328,0.0002813039],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996498,0.000188777,0.0006116024,0.001936364,0.0001231894,0.000181771,0.00005379049,0.00000505517,0.0004014585],"genre_scores_gemma":[0.9994519,0.0001200272,0.00002233601,0.0002023052,0.00003139336,0.00001306099,0.00002367916,0.000007597846,0.0001277127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7764301,"threshold_uncertainty_score":0.206214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05016236729253813,"score_gpt":0.2835489144951377,"score_spread":0.2333865472025995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}