{"id":"W2157682988","doi":"10.1074/jbc.m102503200","title":"Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron 1","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada); Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"","keywords":"ABCA1; Genetically modified mouse; Transgene; Efflux; Promoter; Biology; Intron; Liver X receptor; Molecular biology; Cell biology; Chemistry; Gene; Genetics; Transcription factor; Gene expression; Nuclear receptor; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002509972,0.0005096304,0.0002974943,0.0006066487,0.0001865693,0.0003483005,0.000178248,0.0005033351,0.00355466],"category_scores_gemma":[0.000235927,0.0003025401,0.0002361415,0.0002657611,0.0004280462,0.0001732545,0.0001738855,0.0007361545,0.001179386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001847238,"about_ca_system_score_gemma":0.00011933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004222981,"about_ca_topic_score_gemma":0.0005507168,"domain_scores_codex":[0.9997687,0.00003721127,0.00002605208,0.00005351181,0.00007362584,0.00004083406],"domain_scores_gemma":[0.9997318,0.0000485704,0.00009641725,0.00002981812,0.00002898399,0.00006442059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000113288,0.00003893075,0.0003087602,0.00001906358,0.00000636985,0.0001442242,0.00002143591,0.000016977,0.9979112,0.0001544266,0.00006493989,0.00120036],"study_design_scores_gemma":[0.0001990735,0.0007846659,0.01229151,0.00001523009,0.00008167755,0.004197587,0.00005494648,0.001069264,0.9743341,0.000314812,0.006633645,0.00002351766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904025,0.0006549247,0.006309273,0.0002431855,0.00004755792,0.00003128111,0.0005969727,0.0003907446,0.001323649],"genre_scores_gemma":[0.9835944,0.0008465557,0.005749356,0.0001306968,0.00003978759,0.00008954975,0.001863166,0.0001584033,0.007528138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00355466,"threshold_uncertainty_score":0.01189154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02004980216546525,"score_gpt":0.2712572550883465,"score_spread":0.2512074529228813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}