{"id":"W2157682988","doi":"10.1074/jbc.m102503200","title":"Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron 1","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada); Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"","keywords":"ABCA1; Genetically modified mouse; Transgene; Efflux; Promoter; Biology; Intron; Liver X receptor; Molecular biology; Cell biology; Chemistry; Gene; Genetics; Transcription factor; Gene expression; Nuclear receptor; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001322927,0.0002853506,0.0006691204,0.00007588555,0.00005860363,0.00005427108,0.0002050404,0.0003536187,0.0004532874],"category_scores_gemma":[0.0002410361,0.0002064876,0.0001223225,0.00008285091,0.000119565,0.0001442783,0.00006401479,0.0009188164,0.000003199469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613518,"about_ca_system_score_gemma":0.00004993181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001999337,"about_ca_topic_score_gemma":0.00001767516,"domain_scores_codex":[0.9978105,0.0003108746,0.0008531967,0.0003597235,0.0003137846,0.0003518938],"domain_scores_gemma":[0.9987972,0.00008042871,0.0003781935,0.0001857745,0.0001397344,0.0004186686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01019704,0.0005984865,0.04025554,0.00004419201,0.00008419423,0.0001222955,0.0001715326,0.000001686712,0.9428884,1.616663e-7,0.00004472655,0.005591783],"study_design_scores_gemma":[0.01351463,0.002374971,0.5302871,0.000432436,0.000118149,0.0009403441,0.000162592,0.00008863005,0.4506086,0.00001775211,0.001157564,0.0002971796],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989904,0.0002434846,0.00004034563,0.0003212352,0.00007826064,0.0002716114,0.00001728583,0.00002104936,0.00001637105],"genre_scores_gemma":[0.998473,0.00008593563,0.000274498,0.0003733927,0.0005479456,0.000006304105,0.00003906552,0.00001876306,0.0001811307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4922797,"threshold_uncertainty_score":0.842032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02004980216546525,"score_gpt":0.2712572550883465,"score_spread":0.2512074529228813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}