{"id":"W2157717805","doi":"10.1158/1078-0432.ccr-08-0999","title":"A Phase I Study of the Pan Bcl-2 Family Inhibitor Obatoclax Mesylate in Patients with Advanced Hematologic Malignancies","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Medicine; Refractory (planetary science); Myeloid leukemia; Leukemia; Adverse effect; Internal medicine; Acute leukemia; Chemotherapy; Gastroenterology; Pharmacology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005909641,0.0008754873,0.001278276,0.0002588925,0.0003729853,0.000400209,0.0004371306,0.000516432,0.002302762],"category_scores_gemma":[0.0004830882,0.0003217447,0.0004385661,0.0002904465,0.0006349013,0.0004181202,0.0002360384,0.001440735,0.0004047955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004086369,"about_ca_system_score_gemma":0.000937344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005644442,"about_ca_topic_score_gemma":0.001165111,"domain_scores_codex":[0.9998088,0.00008610558,0.0000113029,0.00002879051,0.00002367481,0.00004123719],"domain_scores_gemma":[0.9996769,0.0000525478,0.00005851462,0.00003076443,0.00001974674,0.0001614395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4994609,0.0505223,0.02379541,0.001098188,0.0009863221,0.0008965007,0.000490767,0.004766031,0.2064193,0.0004963044,0.003092045,0.2079759],"study_design_scores_gemma":[0.4183288,0.5349247,0.02411648,0.00004261473,0.0003708533,0.0008611783,0.00006779191,0.00158628,0.01531954,0.0001767535,0.004178156,0.00002687026],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962156,0.001405333,0.0003399717,0.0001587059,0.00002909916,0.0009520843,0.0001990969,0.00003006069,0.0006699973],"genre_scores_gemma":[0.994165,0.001477854,0.001400383,0.0002651288,0.00007885053,0.001072291,0.0006597548,0.00001028863,0.0008704551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002302762,"threshold_uncertainty_score":0.007703543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09721187264383828,"score_gpt":0.4283978000321723,"score_spread":0.331185927388334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}