{"id":"W2157757731","doi":"10.1084/jem.20150384","title":"CNOT3 contributes to early B cell development by controlling <i>Igh</i> rearrangement and <i>p53</i> mRNA stability","year":2015,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Molecular biology; Immunoglobulin heavy chain; Germline; Gene rearrangement; Messenger RNA; B cell; Cell biology; Gene; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001557155,0.0001257998,0.0002349992,0.00003566995,0.00008564515,0.00001552574,0.0002053003,0.00004056111,0.00001074124],"category_scores_gemma":[0.0001359971,0.00007404093,0.00002718109,0.00006086793,0.0001269972,0.000006956029,0.000108152,0.0001211142,0.000002348189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000599119,"about_ca_system_score_gemma":0.00008374284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006289369,"about_ca_topic_score_gemma":0.000005709548,"domain_scores_codex":[0.9987878,0.0001226805,0.0003768357,0.0001207505,0.0003606079,0.0002313531],"domain_scores_gemma":[0.9991701,0.0000440015,0.0001333229,0.0001537436,0.0001831092,0.000315678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001093339,0.00007261837,0.001069208,0.000004549167,0.00004942415,0.000003393816,0.001004861,0.000002518178,0.9820047,0.00000205782,0.01415274,0.0005405676],"study_design_scores_gemma":[0.003365066,0.001986431,0.0001825135,0.000045562,0.00001696215,0.00001834254,0.003037656,0.000005561906,0.9660423,0.000008121929,0.02521314,0.00007827476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973409,0.02316551,0.0009687289,0.001712277,0.0001315706,0.0002342408,0.000002521149,0.00000233268,0.0003738364],"genre_scores_gemma":[0.9981375,0.0001693261,0.0002788465,0.0009665653,0.0001712747,0.00000615489,0.000004237468,0.00001073221,0.0002553745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0247285,"threshold_uncertainty_score":0.3019302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268834136616009,"score_gpt":0.2851648690088015,"score_spread":0.2624765276426414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}