{"id":"W2157774521","doi":"10.1158/1078-0432.ccr-05-0319","title":"ZD6474, a Novel Tyrosine Kinase Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor, Inhibits Tumor Growth of Multiple Nervous System Tumors","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Vascular endothelial growth factor; Epidermal growth factor receptor; Angiogenesis; Cancer research; Epidermal growth factor; Receptor tyrosine kinase; Glioma; Growth factor receptor; Biology; Growth factor receptor inhibitor; Tyrosine kinase; Medicine; Internal medicine; Receptor; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001518938,0.0004209381,0.0009430411,0.0001960287,0.0001772383,0.00003883208,0.00056591,0.0004353679,0.0001672129],"category_scores_gemma":[0.002436242,0.0003650138,0.0005389761,0.0004304422,0.0009479626,0.00003217368,0.0005463875,0.0005418864,0.00001766616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001547637,"about_ca_system_score_gemma":0.0006561769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009903269,"about_ca_topic_score_gemma":0.0001664281,"domain_scores_codex":[0.9951177,0.0005589763,0.001468101,0.001099221,0.0009104763,0.0008455893],"domain_scores_gemma":[0.996399,0.0005304039,0.000454535,0.0006041617,0.001504772,0.0005070632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00147533,0.0006045172,0.104626,0.0008785901,0.0002559881,0.000004825552,0.0001106408,0.000006398605,0.8849431,0.000227871,0.003174872,0.003691826],"study_design_scores_gemma":[0.003769613,0.001230102,0.02747783,0.0004522913,0.00004016619,0.000007889579,0.0001386922,0.00009657614,0.958361,0.000007420011,0.007949472,0.0004689511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901775,0.006198812,0.0002069734,0.0003889714,0.0004285394,0.0007858432,0.00170646,0.00002710013,0.00007977378],"genre_scores_gemma":[0.9929872,0.002887952,0.001020101,0.0001456476,0.002418443,0.0001744285,0.0000802935,0.0001017922,0.0001842142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0771482,"threshold_uncertainty_score":0.9998802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06965143392391154,"score_gpt":0.367977038097077,"score_spread":0.2983256041731654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}