{"id":"W2157774521","doi":"10.1158/1078-0432.ccr-05-0319","title":"ZD6474, a Novel Tyrosine Kinase Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor, Inhibits Tumor Growth of Multiple Nervous System Tumors","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Vascular endothelial growth factor; Epidermal growth factor receptor; Angiogenesis; Cancer research; Epidermal growth factor; Receptor tyrosine kinase; Glioma; Growth factor receptor; Biology; Growth factor receptor inhibitor; Tyrosine kinase; Medicine; Internal medicine; Receptor; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009082846,0.0004462261,0.000328345,0.0003887177,0.0001273524,0.0001500962,0.0003218392,0.0001767372,0.0008523344],"category_scores_gemma":[0.00007443979,0.0000821548,0.0002690458,0.0002192135,0.0001778911,0.0001423788,0.00008493941,0.0003860502,0.0002409926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264495,"about_ca_system_score_gemma":0.0003735214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000982929,"about_ca_topic_score_gemma":0.00230794,"domain_scores_codex":[0.9999572,0.000004961051,0.000004093752,0.000005405138,0.00001292868,0.00001555715],"domain_scores_gemma":[0.999958,0.000005408965,0.00001482044,0.00000297126,0.000005935669,0.00001279119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001461522,0.0009594006,0.001218727,0.0002850468,0.00005331185,0.0001773556,0.00001258068,0.001272898,0.9621904,0.0001687998,0.0005439461,0.03165598],"study_design_scores_gemma":[0.001216618,0.01138622,0.01264972,0.00001925783,0.0001430749,0.0009418221,0.00002251133,0.002853677,0.9630827,0.00007306963,0.007597301,0.00001401674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902384,0.005711433,0.002049639,0.0001039621,0.000065316,0.00009007489,0.000313344,0.0001700518,0.001257673],"genre_scores_gemma":[0.9873418,0.006217562,0.002505068,0.0000645598,0.00003418412,0.0000661338,0.001061243,0.00001549426,0.002694075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000982929,"threshold_uncertainty_score":0.002851367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06965143392391154,"score_gpt":0.367977038097077,"score_spread":0.2983256041731654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}