{"id":"W2157776316","doi":"10.1517/17425250903273160","title":"Saquinavir, the pioneer antiretroviral protease inhibitor","year":2009,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Saquinavir; Tolerability; Protease inhibitor (pharmacology); Medicine; Pill; Pharmacology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Protease; ANTIRETROVIRAL AGENTS; Intensive care medicine; Virology; Viral load; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005286444,0.0007112327,0.0008834006,0.001731761,0.0002197178,0.0006765379,0.0006628692,0.0008722765,0.003366691],"category_scores_gemma":[0.0005512355,0.0002053712,0.0003816882,0.001523595,0.0003222014,0.0007649095,0.0003347321,0.001004973,0.00332463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003620423,"about_ca_system_score_gemma":0.0007765671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007458765,"about_ca_topic_score_gemma":0.001073795,"domain_scores_codex":[0.9996997,0.00005218358,0.00003487715,0.00005959263,0.0001324777,0.00002109902],"domain_scores_gemma":[0.9996355,0.0001389013,0.00007604765,0.000009172298,0.0001107113,0.00002967248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000541188,0.00004841301,0.0002817648,0.01050667,0.0000527224,0.0003883358,0.00004389756,0.0001866083,0.003994442,0.001362876,0.01571814,0.967362],"study_design_scores_gemma":[0.00002781383,0.0001852595,0.001178156,0.00204219,0.00009601525,0.005596068,0.00004700225,0.0000905018,0.001588784,0.001011625,0.9881196,0.00001700302],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001618341,0.9977844,0.0001527277,0.0002673585,0.00016851,0.000005491169,0.0000111765,0.000008375636,0.001440141],"genre_scores_gemma":[0.001966488,0.9960312,0.0004073198,0.0002489191,0.0003532672,0.000006082867,0.0000297408,0.000001513175,0.0009555284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003366691,"threshold_uncertainty_score":0.01126266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04191738453821527,"score_gpt":0.3556561561045075,"score_spread":0.3137387715662923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}