{"id":"W2157825687","doi":"10.1186/ar1345","title":"ALXR, a common GPCR gateway for antiinflammatory and/or proinflammatory cell activation: relevance of selective kinase and phospholipase signaling by uteroglobin, lipoxin A(4 )and serum amyloid A in ALXR-mediated chemotaxis","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Annexin A1; Proinflammatory cytokine; Phospholipase A2; Phosphorylation; Chemistry; Annexin; Lipoxin; Phospholipase; Kinase; MAPK/ERK pathway; Uteroglobin; Protein kinase B; Cell biology; Signal transduction; Receptor; Biochemistry; Inflammation; Biology; Enzyme; Cell; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007725084,0.0005636055,0.0005387849,0.0004925695,0.0004852338,0.00124749,0.0007952406,0.001044268,0.006689023],"category_scores_gemma":[0.000277658,0.000180724,0.0008019728,0.0001813756,0.0006153575,0.001206112,0.001017035,0.001013471,0.001640736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006318634,"about_ca_system_score_gemma":0.0003900305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003875075,"about_ca_topic_score_gemma":0.0002808545,"domain_scores_codex":[0.9994285,0.0001214837,0.00003324874,0.0001117613,0.00008769699,0.0002173853],"domain_scores_gemma":[0.9997914,0.00003303155,0.00007073076,0.00001082724,0.00002157936,0.00007251866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001573606,0.0002708283,0.003962633,0.00108687,0.00005279085,0.002114119,0.0003776581,0.000725036,0.9562801,0.008515613,0.002879604,0.02216116],"study_design_scores_gemma":[0.0006914035,0.006496584,0.2021591,0.00067899,0.0002666724,0.01747148,0.00303927,0.0230575,0.6408482,0.009046914,0.09606103,0.000182864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9081269,0.05521644,0.01797368,0.005000676,0.0005620677,0.0002674782,0.001008583,0.0003396677,0.01150454],"genre_scores_gemma":[0.9703087,0.01305471,0.006908488,0.0008530162,0.0003653813,0.0001415039,0.001041856,0.00002379179,0.007302526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006689023,"threshold_uncertainty_score":0.02237695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406255342813242,"score_gpt":0.2826129564867329,"score_spread":0.2685504030586005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}