{"id":"W2157825687","doi":"10.1186/ar1345","title":"ALXR, a common GPCR gateway for antiinflammatory and/or proinflammatory cell activation: relevance of selective kinase and phospholipase signaling by uteroglobin, lipoxin A(4 )and serum amyloid A in ALXR-mediated chemotaxis","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Annexin A1; Proinflammatory cytokine; Phospholipase A2; Phosphorylation; Chemistry; Annexin; Lipoxin; Phospholipase; Kinase; MAPK/ERK pathway; Uteroglobin; Protein kinase B; Cell biology; Signal transduction; Receptor; Biochemistry; Inflammation; Biology; Enzyme; Cell; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006351534,0.0001657007,0.000251324,0.0001284845,0.0001083002,0.00003604947,0.0001015298,0.0001770917,0.000004678606],"category_scores_gemma":[0.0002522555,0.0001666358,0.00002923678,0.0002372782,0.0002632374,0.00002746849,0.000133626,0.0002447747,7.0699e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003818517,"about_ca_system_score_gemma":0.0001768114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003152986,"about_ca_topic_score_gemma":0.0009028807,"domain_scores_codex":[0.9984796,0.0001058708,0.00031539,0.0004761232,0.0001889944,0.0004340099],"domain_scores_gemma":[0.9993653,0.0001007646,0.00007731229,0.0001852673,0.0001507836,0.000120619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000713475,0.0001569277,0.005006457,0.0002075449,0.00001240329,0.00003455891,0.0003984131,0.00001264493,0.9846951,0.00002673192,0.0001479916,0.008587718],"study_design_scores_gemma":[0.004360591,0.0009167034,0.003264011,0.0003465566,0.000001496692,0.00001529425,0.0003449757,0.0000890383,0.9881906,0.0002484701,0.00203071,0.0001915492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920288,0.006629213,0.00003521475,0.0002112295,0.00001079599,0.0009599932,0.0000655689,0.00000780956,0.00005135359],"genre_scores_gemma":[0.9938226,0.005292112,0.0004413263,0.00004899152,0.00003863156,0.0002144854,0.00004180079,0.00002824188,0.00007181051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008396169,"threshold_uncertainty_score":0.679521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406255342813242,"score_gpt":0.2826129564867329,"score_spread":0.2685504030586005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}