{"id":"W2157838834","doi":"10.1038/nsmb.2042","title":"Recognition and maturation of effector RNAs in a CRISPR interference pathway","year":2011,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Trans-activating crRNA; Biology; CRISPR interference; Effector; Thermus thermophilus; Genetics; RNA; Endonuclease; Gene; RNA silencing; RNA interference; Gene silencing; Argonaute; Cas9; Computational biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007119587,0.0004136452,0.0004379675,0.0002940875,0.0005568665,0.001896775,0.0005457878,0.0009504415,0.001667547],"category_scores_gemma":[0.0006968782,0.0005707293,0.0005134142,0.0002070298,0.0004753404,0.000698655,0.0006008029,0.001861443,0.001911078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001079589,"about_ca_system_score_gemma":0.000591261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003980074,"about_ca_topic_score_gemma":0.000791524,"domain_scores_codex":[0.9992802,0.0000876355,0.00006480388,0.0001774958,0.0002642817,0.0001255488],"domain_scores_gemma":[0.9994886,0.0001196393,0.00009226248,0.000105292,0.00008390986,0.0001103314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001002601,0.00002431039,0.0001265662,0.00002317856,0.000003971061,0.0001017108,0.00003102137,0.0002496645,0.995363,0.001608985,0.0001858379,0.002181566],"study_design_scores_gemma":[0.00001046727,0.00003544855,0.0004140415,0.000003266351,0.000005432723,0.0001362835,0.00001694985,0.001663186,0.9945824,0.0003314012,0.002790677,0.00001047345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.834033,0.001726839,0.1412567,0.0009083198,0.0004398099,0.0002489307,0.0005695049,0.00204301,0.01877393],"genre_scores_gemma":[0.9500273,0.00049493,0.03721224,0.0002649333,0.00003973285,0.00007949516,0.0006834434,0.0003028385,0.01089502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001896775,"threshold_uncertainty_score":0.007833004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008358641331487102,"score_gpt":0.3079317160207856,"score_spread":0.2995730746892984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}