{"id":"W2157838834","doi":"10.1038/nsmb.2042","title":"Recognition and maturation of effector RNAs in a CRISPR interference pathway","year":2011,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Trans-activating crRNA; Biology; CRISPR interference; Effector; Thermus thermophilus; Genetics; RNA; Endonuclease; Gene; RNA silencing; RNA interference; Gene silencing; Argonaute; Cas9; Computational biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007061136,0.0001423896,0.0001517891,0.00007394947,0.00001395433,0.000004329777,0.0001001244,0.0003883396,0.00001602565],"category_scores_gemma":[0.00009092312,0.0001237093,0.00004550879,0.00007695075,0.00006646372,0.000003318298,0.00006774714,0.0002117922,0.0000011077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006105799,"about_ca_system_score_gemma":0.00001489779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003814921,"about_ca_topic_score_gemma":0.00004037967,"domain_scores_codex":[0.999281,0.00006576402,0.0001778262,0.0002764619,0.00003818994,0.0001607658],"domain_scores_gemma":[0.9996828,0.000006554569,0.00005900064,0.0001564679,0.00005778707,0.00003742204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001246792,0.000005255434,0.001128761,0.00002611525,0.00001859162,0.000003926306,0.00008110862,0.000002636042,0.9873879,0.0002622337,0.000008352902,0.01095047],"study_design_scores_gemma":[0.0003588594,0.0003342913,0.02601619,0.00002065705,0.000008712987,0.00003657298,0.00002292232,0.00004497811,0.9711283,0.001743234,0.0001366424,0.0001486279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896024,0.002529947,0.007264894,0.00002172855,0.0002063768,0.0001606397,0.00003185902,0.000007543923,0.0001745827],"genre_scores_gemma":[0.9972922,0.00005456871,0.002293756,0.000103725,0.0000413346,0.000009573275,0.0001882042,0.00001147124,0.000005230945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02488743,"threshold_uncertainty_score":0.5044718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008358641331487102,"score_gpt":0.3079317160207856,"score_spread":0.2995730746892984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}