{"id":"W2157877362","doi":"10.3390/ijms14047492","title":"Epigenetic Silencing of DKK3 in Medulloblastoma","year":2013,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca; Ministero della Salute","keywords":"Epigenetics; Trichostatin A; Wnt signaling pathway; DNA methylation; Biology; Downregulation and upregulation; microRNA; Gene silencing; DKK1; Chromatin; Methylation; Cancer research; Histone deacetylase; Histone; Medulloblastoma; MECP2; Promoter; Gene; Genetics; Molecular biology; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044459,0.0001627505,0.0002525168,0.0002483338,0.0001243695,0.0002161929,0.0001035176,0.0001113561,0.0004514679],"category_scores_gemma":[0.0001573881,0.0001004378,0.000196998,0.0001956726,0.0001522197,0.00009321159,0.0001928703,0.000185009,0.0001321945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003510558,"about_ca_system_score_gemma":0.0002315923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002145,"about_ca_topic_score_gemma":0.003866358,"domain_scores_codex":[0.9999083,0.000009216009,0.000007815545,0.0000276191,0.00003014353,0.00001680417],"domain_scores_gemma":[0.9999363,0.000009833409,0.00002886608,0.00000657945,0.000007251752,0.00001108209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002244223,0.000008913101,0.004917772,0.00005902164,0.0000199738,0.00005576504,0.00002886835,0.0001345547,0.9912548,0.00005400569,0.00004053748,0.003201364],"study_design_scores_gemma":[0.00002437426,0.000262493,0.2015007,0.00001225741,0.0001143944,0.0005319041,0.00008931197,0.001363077,0.7913668,0.0001073271,0.004617395,0.00001000031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961671,0.001799695,0.0009054689,0.00002183071,0.000006659279,0.000008774294,0.0005624215,0.00003350466,0.0004944772],"genre_scores_gemma":[0.9979423,0.0006690305,0.000480657,0.00001461962,0.00000238655,0.000009092932,0.0004552664,0.000009072697,0.0004176321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002145,"threshold_uncertainty_score":0.00426501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009285273980224537,"score_gpt":0.2769356174662106,"score_spread":0.267650343485986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}