{"id":"W2157886083","doi":"10.1128/jvi.01169-09","title":"A Proteomic Approach To Identify Candidate Substrates of Human Adenovirus E4orf6-E1B55K and Other Viral Cullin-Based E3 Ubiquitin Ligases","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Cullin; Ubiquitin ligase; Biology; Ubiquitin; DNA ligase; Cell biology; Molecular biology; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006433403,0.0001928555,0.0003774917,0.0002285321,0.00007131218,0.00002772739,0.0003513261,0.0002007295,0.00003058336],"category_scores_gemma":[0.00005701361,0.0001669763,0.0001330568,0.000105848,0.0001788301,0.000007101637,0.00004319764,0.000242464,0.000003336577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001972032,"about_ca_system_score_gemma":0.0001993699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002932235,"about_ca_topic_score_gemma":0.00004955232,"domain_scores_codex":[0.9984136,0.0002242728,0.0005311466,0.0002648654,0.0002215867,0.0003444828],"domain_scores_gemma":[0.9990554,0.00001484794,0.0003397092,0.0002682128,0.0001475821,0.0001742114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00351105,0.0002794435,0.002858134,0.00002174376,0.00008511301,0.00001527318,0.0000605256,0.0003408986,0.9919173,0.00004470494,0.0003179392,0.0005479302],"study_design_scores_gemma":[0.001717587,0.01273086,0.0126204,0.00002381141,0.00003443385,0.0001106084,0.00003000431,0.00004654776,0.9718761,0.0003431302,0.0003060706,0.000160462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978728,0.0008798337,0.0002656545,0.0004774137,0.00003814028,0.0002755428,0.00002275091,0.000004386223,0.0001635281],"genre_scores_gemma":[0.9976808,0.00004833943,0.0007026541,0.001211663,0.0002631268,0.000009343681,0.000009349527,0.00002465182,0.00005011028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02004115,"threshold_uncertainty_score":0.6809095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02313083188014371,"score_gpt":0.3390259096524274,"score_spread":0.3158950777722837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}