{"id":"W2157886083","doi":"10.1128/jvi.01169-09","title":"A Proteomic Approach To Identify Candidate Substrates of Human Adenovirus E4orf6-E1B55K and Other Viral Cullin-Based E3 Ubiquitin Ligases","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Cullin; Ubiquitin ligase; Biology; Ubiquitin; DNA ligase; Cell biology; Molecular biology; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004489297,0.000630405,0.0004763322,0.0009218081,0.0004174355,0.0005059422,0.0003509384,0.0004192503,0.0008001313],"category_scores_gemma":[0.0003191978,0.0002651024,0.0005518618,0.0005549648,0.0001731768,0.0003865785,0.0002715851,0.0003768819,0.0004750698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003626883,"about_ca_system_score_gemma":0.0002223212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008284091,"about_ca_topic_score_gemma":0.001288406,"domain_scores_codex":[0.9997786,0.00003381689,0.0000348996,0.00004982175,0.00006337469,0.00003950214],"domain_scores_gemma":[0.999832,0.00003358353,0.00002648937,0.00001768383,0.00005850875,0.00003168023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001034332,0.00002352126,0.0006497131,0.00005605679,0.00001297875,0.00007561797,0.00001624727,0.00002826227,0.9979024,0.00004479465,0.00002431321,0.001062679],"study_design_scores_gemma":[0.00002012031,0.0002601906,0.02609028,0.00001326168,0.00007370448,0.001403436,0.0001505985,0.002299187,0.9659324,0.0001218853,0.003615968,0.00001892389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755131,0.005455312,0.01542633,0.0002522359,0.00007781904,0.0001615582,0.001352148,0.00009627797,0.001665248],"genre_scores_gemma":[0.923162,0.004104084,0.06507443,0.0002674923,0.00004016828,0.000167672,0.003703959,0.00004268818,0.003437468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009218081,"threshold_uncertainty_score":0.002676725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02313083188014371,"score_gpt":0.3390259096524274,"score_spread":0.3158950777722837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}