{"id":"W2157894448","doi":"10.2337/db07-1762","title":"Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and β-Cell Death","year":2008,"lang":"en","type":"article","venue":"Diabetes","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canadian Diabetes Association","keywords":"Unfolded protein response; Endoplasmic reticulum; SERCA; Thapsigargin; Cell biology; Ryanodine receptor; Caspase 12; Programmed cell death; Biology; Apoptosis; Chemistry; Caspase; Biochemistry; ATPase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000400813,0.0005327442,0.0004338612,0.0001940412,0.0001625929,0.0003898833,0.0002257885,0.000455827,0.0006665371],"category_scores_gemma":[0.0002223561,0.0000999004,0.0003946345,0.0001404276,0.0003682381,0.0004165689,0.0002945516,0.0006902352,0.0002511719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002957557,"about_ca_system_score_gemma":0.0001827445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001338143,"about_ca_topic_score_gemma":0.0001741915,"domain_scores_codex":[0.9997776,0.00004834663,0.000031508,0.00004262854,0.00004588276,0.00005408661],"domain_scores_gemma":[0.9997798,0.00002872497,0.00008519366,0.00002297255,0.00003809667,0.00004516574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001274057,0.0001140655,0.001475335,0.0003534836,0.00004927108,0.0004340581,0.00005286236,0.0002495543,0.9813014,0.0004147243,0.0002129673,0.01406835],"study_design_scores_gemma":[0.000279133,0.002884938,0.06450528,0.0001126766,0.0002516303,0.003287973,0.0002556,0.002643151,0.9105465,0.001413464,0.01379044,0.00002925642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9054787,0.08255109,0.007194095,0.0008186442,0.0001660225,0.00008516508,0.0002804273,0.0001524408,0.003273403],"genre_scores_gemma":[0.9689575,0.02459053,0.003553093,0.0004053162,0.00009796277,0.000133507,0.0002632854,0.00002028888,0.001978599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006665371,"threshold_uncertainty_score":0.00222975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006225843140448205,"score_gpt":0.203904498527187,"score_spread":0.1976786553867388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}