{"id":"W2157908451","doi":"10.1016/s0378-5173(03)00037-1","title":"Influence of cimetidine co-administration on the pharmacokinetics of acebutolol enantiomers and its metabolite diacetolol in a rat model: the effect of gastric pH on double-peak phenomena","year":2003,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Pharmacokinetics; Metabolite; Oral administration; Cimetidine; Chemistry; Pharmacology; Active metabolite; Absorption (acoustics); Urine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001334966,0.0002069572,0.00046088,0.0003896189,0.00002803798,0.0000135992,0.0003250081,0.00005322817,0.00002627221],"category_scores_gemma":[0.0003030729,0.000121232,0.0001515708,0.0003185942,0.0001869495,0.00007837055,0.0000346488,0.0004874379,0.000001285299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004904463,"about_ca_system_score_gemma":0.0001347186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001557909,"about_ca_topic_score_gemma":1.995192e-7,"domain_scores_codex":[0.9977086,0.0002171398,0.0009045663,0.00013884,0.0008470249,0.000183889],"domain_scores_gemma":[0.9976268,0.000652176,0.0009125316,0.0001381768,0.000568742,0.0001015571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006100603,0.0006410828,0.007081409,0.0001783049,0.0006512696,0.00004154338,0.0004297046,0.09120635,0.8871648,0.00435024,0.00006208544,0.002092657],"study_design_scores_gemma":[0.007176394,0.0008860104,0.001463063,0.0002264597,0.0004348141,0.000116489,0.00004244497,0.02373066,0.9649671,0.00003184903,0.0008357919,0.0000889597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966419,0.0008663152,0.0001440803,0.001075454,0.0002276492,0.0004689608,0.00004042422,0.000003039165,0.0005322141],"genre_scores_gemma":[0.9964861,0.00303088,0.00007358985,0.0002620475,0.00008647902,0.000002631767,0.000003905471,0.00001872839,0.00003567682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07780232,"threshold_uncertainty_score":0.4943696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03396889164593091,"score_gpt":0.3724057885134122,"score_spread":0.3384368968674812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}