{"id":"W2157912932","doi":"10.3109/10428194.2014.971407","title":"The deregulated promoter methylation of the<i>Polo-like kinases</i>as a potential biomarker in hematological malignancies","year":2014,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Windsor Regional Hospital; University of Windsor","funders":"Windsor Cancer Centre Foundation","keywords":"Polo-like kinase; Methylation; DNA methylation; Carcinogenesis; PLK1; Biology; Cancer research; Leukemia; Kinase; Biomarker; Myelodysplastic syndromes; Bone marrow; Molecular biology; Cancer; Genetics; Immunology; DNA; Gene; Cell cycle; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002991346,0.0002116188,0.0001530616,0.0007389826,0.0001193674,0.0003156595,0.0001573878,0.0002066042,0.000712558],"category_scores_gemma":[0.0003692441,0.0001218488,0.00009586637,0.0004500617,0.0002246112,0.0002333411,0.0001544854,0.0002512622,0.0001516066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001485549,"about_ca_system_score_gemma":0.000109134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004662219,"about_ca_topic_score_gemma":0.0005198105,"domain_scores_codex":[0.9998699,0.00004056327,0.00001250144,0.00002768236,0.00002716817,0.00002206929],"domain_scores_gemma":[0.9998535,0.00003694422,0.00006310857,0.000009214273,0.00001704836,0.00002028247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008218786,0.00004887372,0.1657545,0.0001513733,0.00005350862,0.0002529163,0.00009342247,0.0002375456,0.8196464,0.000124049,0.00008329223,0.01273225],"study_design_scores_gemma":[0.00002169974,0.0006705729,0.5354369,0.00002395446,0.0001208385,0.002525932,0.0002366992,0.001711406,0.456623,0.000374985,0.002241615,0.00001244576],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938086,0.003239252,0.001862134,0.00005835426,0.000007226211,0.00001964618,0.0002472324,0.0000342253,0.0007233517],"genre_scores_gemma":[0.9978315,0.0006160546,0.001019014,0.00002093568,0.000006857696,0.00001211341,0.0002298621,0.000003231398,0.0002603521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007389826,"threshold_uncertainty_score":0.002383709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112684306852352,"score_gpt":0.2545168655827003,"score_spread":0.2432484348974651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}