{"id":"W2157917711","doi":"10.1158/0008-5472.can-06-0402","title":"Restoration of Tamoxifen Sensitivity in Estrogen Receptor–Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Institutes of Health; Breast Cancer Research Foundation","keywords":"Trichostatin A; Corepressor; Tamoxifen; Cancer research; Estrogen receptor; Histone deacetylase; Chromatin immunoprecipitation; Breast cancer; Estrogen receptor alpha; Biology; Antiestrogen; Cancer; Chemistry; Histone; Nuclear receptor; Promoter; Gene expression; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001396371,0.0002756391,0.0003861819,0.0002992671,0.0002286375,0.00005266776,0.0003000263,0.0002974206,0.0001600301],"category_scores_gemma":[0.0003149035,0.0002797221,0.000100568,0.0008938252,0.0009778722,0.00003223305,0.0002946275,0.0006633422,0.00002118471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007928699,"about_ca_system_score_gemma":0.000944581,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04102963,"about_ca_topic_score_gemma":0.01596328,"domain_scores_codex":[0.995849,0.001081366,0.0004846188,0.0008787168,0.0009233499,0.0007830193],"domain_scores_gemma":[0.9973878,0.0002149941,0.0002039599,0.0006084066,0.001420336,0.0001644601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001483603,0.0002596473,0.007951131,0.00007037353,0.0000574259,0.00002016542,0.0002733817,0.0007264774,0.9764591,0.00005866075,0.01172169,0.0009183629],"study_design_scores_gemma":[0.0009719637,0.0001545137,0.0259431,0.0001663966,0.000008240666,0.000007259245,0.000145475,0.0001327335,0.9695845,0.0001238353,0.002489552,0.0002724772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957713,0.0005805267,0.00004917042,0.0004010847,0.0001569049,0.001009194,0.001188644,0.0000185786,0.0008245604],"genre_scores_gemma":[0.9968467,0.0002486338,0.0001127086,0.00001602785,0.0005801147,0.000495484,0.0003154673,0.00006539717,0.001319451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02506634,"threshold_uncertainty_score":0.9999655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04252161863250627,"score_gpt":0.3649431247391933,"score_spread":0.322421506106687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}