{"id":"W2157932545","doi":"10.1177/00912700022009558","title":"Who Needs Individual Bioequivalence Studies for Narrow Therapeutic Index Drugs? A Case for Warfarin","year":2000,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Sainte Foy","funders":"","keywords":"Bioequivalence; Warfarin; Medicine; Pharmacokinetics; Crossover study; Pharmacology; Therapeutic index; Replicate; CYP2C9; Internal medicine; Drug; Statistics; Mathematics; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2673818,0.0008919906,0.007012502,0.002321317,0.002076427,0.00637444,0.004801951,0.02210084,0.002570883],"category_scores_gemma":[0.3001836,0.000988311,0.003470079,0.002306759,0.01375246,0.02072443,0.003239846,0.01620254,0.0008176496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00312832,"about_ca_system_score_gemma":0.005889179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001645582,"about_ca_topic_score_gemma":0.002816782,"domain_scores_codex":[0.8584155,0.09531488,0.01152141,0.006790617,0.02591956,0.002037965],"domain_scores_gemma":[0.6887141,0.2358036,0.01508819,0.02848173,0.02573101,0.006181263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004494204,0.0009671533,0.02304313,0.00233434,0.00090799,0.004280834,0.002897549,0.001719551,0.003176363,0.07401786,0.04896589,0.8331951],"study_design_scores_gemma":[0.004149545,0.0106247,0.03785471,0.008150579,0.001678137,0.02943032,0.007291748,0.01819642,0.006195707,0.5793167,0.2962894,0.0008221057],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03748107,0.09648057,0.06676552,0.7813951,0.004107359,0.0006470506,0.0001754857,0.0003642361,0.01258362],"genre_scores_gemma":[0.4402726,0.04866009,0.2238517,0.2646632,0.01660628,0.001929339,0.0002476187,0.0004452332,0.003323856],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2673818,"threshold_uncertainty_score":0.9034486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.421124098491936,"score_gpt":0.5880239667940168,"score_spread":0.1668998683020808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}