{"id":"W2157946922","doi":"10.1086/375072","title":"Severe Hepatotoxicity Associated with Rifampin-Pyrazinamide Preventative Therapy Requiring Transplantation in an Individual at Low Risk for Hepatotoxicity","year":2003,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Capital District Health Authority; University of Alberta Hospital; University of Alberta","funders":"","keywords":"Medicine; Pyrazinamide; Liver transplantation; Transplantation; Internal medicine; Liver disease; Pharmacology; Disease; Therapeutic drug monitoring; Immunology; Intensive care medicine; Drug; Tuberculosis; Isoniazid; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002720975,0.000490795,0.0007307806,0.0001983424,0.0008744912,0.00006670912,0.0002427375,0.0008148763,0.0002549395],"category_scores_gemma":[0.001447791,0.0004638072,0.0003414771,0.0005100193,0.0004255513,0.000580364,0.00003327284,0.001370914,0.0000270175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004081292,"about_ca_system_score_gemma":0.0002787283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008160535,"about_ca_topic_score_gemma":0.002833046,"domain_scores_codex":[0.992533,0.004532201,0.0009950815,0.0008950259,0.0002971314,0.0007475234],"domain_scores_gemma":[0.9951462,0.003135142,0.0006754841,0.0002986671,0.0002163935,0.0005280758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001994233,0.004203385,0.9820096,0.00008958822,0.0004492705,0.00004063556,0.0009005081,0.002021901,0.0008916674,0.0001729795,0.00006178507,0.007164385],"study_design_scores_gemma":[0.01753196,0.003167003,0.9469031,0.0001566315,0.0005902491,0.00002436255,0.000159469,0.002675316,0.02189638,0.005335515,0.0005244261,0.001035591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931662,0.0001385373,0.0009804347,0.00002959692,0.0007736458,0.002960021,0.001268824,0.0003223228,0.0003603981],"genre_scores_gemma":[0.996295,0.001025203,0.00004991166,0.001031085,0.0001814316,0.0008862208,0.0003936993,0.00006797918,0.00006940524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03510656,"threshold_uncertainty_score":0.9997814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1722437410042079,"score_gpt":0.4636319091460722,"score_spread":0.2913881681418643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}