{"id":"W2157955877","doi":"10.2337/db13-1807","title":"Prohibitin Overexpression in Adipocytes Induces Mitochondrial Biogenesis, Leads to Obesity Development, and Affects Glucose Homeostasis in a Sex-Specific Manner","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Adipocyte; Adipose tissue; Endocrinology; Internal medicine; Mitochondrion; Prohibitin; Biology; Glucose homeostasis; Mitochondrial biogenesis; Energy homeostasis; Downregulation and upregulation; Adiponectin; Homeostasis; Insulin resistance; Cell biology; White adipose tissue; Insulin; Obesity; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002777058,0.0002408534,0.0004935419,0.0004091248,0.00005796171,0.00003167134,0.0000898764,0.0001577135,0.00002878992],"category_scores_gemma":[0.0001710902,0.0002068069,0.00003532073,0.0003658292,0.00004552203,0.0001240228,0.0001001324,0.0001637687,0.00005656428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004918309,"about_ca_system_score_gemma":0.000047866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002594963,"about_ca_topic_score_gemma":0.00004594122,"domain_scores_codex":[0.9984612,0.0001161153,0.0002731784,0.000469589,0.0002155208,0.0004643604],"domain_scores_gemma":[0.9993283,0.0001351721,0.00005996108,0.0002334464,0.00002939743,0.0002137422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000082878,0.000221833,0.1785222,0.0001475086,0.00001557161,0.00001354363,0.001331671,9.292712e-7,0.7409891,0.0000842439,0.0008156949,0.07777483],"study_design_scores_gemma":[0.001389958,0.00009215677,0.2981897,0.0005832542,0.00001190344,0.000001256218,0.00005080256,0.000005241863,0.6759838,0.00003642317,0.02346557,0.0001898581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909514,0.007828219,0.000005089757,0.0001697149,0.0001183687,0.0006883438,0.000006660727,0.00004471043,0.000187446],"genre_scores_gemma":[0.9965023,0.000154927,0.002424432,0.0003010784,0.0002611677,0.0001082289,0.00003627636,0.0000317553,0.0001798348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1196675,"threshold_uncertainty_score":0.8433341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531280756049896,"score_gpt":0.2477384682032037,"score_spread":0.2324256606427047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}