{"id":"W2157980542","doi":"10.1095/biolreprod.111.096602","title":"Loss of Genomic Imprinting in Mouse Embryos with Fast Rates of Preimplantation Development in Culture1","year":2012,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Institute of Gender and Health; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute","keywords":"Genomic imprinting; Embryo; Biology; Imprinting (psychology); Embryogenesis; Andrology; Embryo culture; Genetics; Embryonic stem cell; Methylation; Inner cell mass; Blastocyst; Cell fate determination; Epigenetics; DNA methylation; Cell biology; Gene expression; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004136082,0.0004824826,0.0003742834,0.0008520701,0.0002236532,0.0004011102,0.0004727156,0.0003978619,0.001073132],"category_scores_gemma":[0.0003234973,0.0003953013,0.0005014206,0.0003417097,0.0002318046,0.0002651557,0.0003017796,0.0008983728,0.0007394024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003384963,"about_ca_system_score_gemma":0.0001857919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008510801,"about_ca_topic_score_gemma":0.001212247,"domain_scores_codex":[0.9996002,0.00004260622,0.00006169361,0.00009563808,0.0001365923,0.00006320297],"domain_scores_gemma":[0.9995097,0.0001529991,0.0001388014,0.0001049546,0.00003509927,0.00005842756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007221723,0.00001022505,0.0008210934,0.00001756439,0.00000709516,0.00005160552,0.00001865899,0.00003808045,0.9980769,0.00005005042,0.00001576698,0.0008206714],"study_design_scores_gemma":[0.00001083839,0.0003367947,0.03505088,0.00001170421,0.00003653371,0.0006142862,0.00002824353,0.000811993,0.960943,0.00006771491,0.00207987,0.000008035531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698695,0.006680971,0.01771433,0.000094282,0.00005344616,0.0001147302,0.002708067,0.000284489,0.00248012],"genre_scores_gemma":[0.9727844,0.00322408,0.01335508,0.0001141658,0.00002456124,0.0002820891,0.003643748,0.0001709479,0.006400877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073132,"threshold_uncertainty_score":0.003589928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314233626520992,"score_gpt":0.2533268614587991,"score_spread":0.2401845251935892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}