{"id":"W2157980542","doi":"10.1095/biolreprod.111.096602","title":"Loss of Genomic Imprinting in Mouse Embryos with Fast Rates of Preimplantation Development in Culture1","year":2012,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Institute of Gender and Health; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute","keywords":"Genomic imprinting; Embryo; Biology; Imprinting (psychology); Embryogenesis; Andrology; Embryo culture; Genetics; Embryonic stem cell; Methylation; Inner cell mass; Blastocyst; Cell fate determination; Epigenetics; DNA methylation; Cell biology; Gene expression; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003413647,0.00007147333,0.0001454193,0.00006818798,0.000009721565,8.13439e-7,0.00005546986,0.000083481,0.000002455366],"category_scores_gemma":[0.00004649144,0.00006091957,0.00001800548,0.00006452464,0.00006354119,0.000004202194,0.00004189932,0.00003857225,4.959411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009603987,"about_ca_system_score_gemma":0.00003292338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000844556,"about_ca_topic_score_gemma":0.00003748789,"domain_scores_codex":[0.9992801,0.0000423066,0.0003065699,0.0002045932,0.00003263935,0.0001337847],"domain_scores_gemma":[0.9995367,0.000003946806,0.0002256358,0.0001623083,0.00005820557,0.00001322915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001963746,0.00003848869,0.4151746,0.0000337908,0.00001092007,2.495623e-8,0.0002606655,0.00007064694,0.5796621,0.000007346685,6.03077e-7,0.004721172],"study_design_scores_gemma":[0.0001892921,0.00007369252,0.4110538,0.00001100951,0.00000193637,0.00001565699,0.0001951578,0.000002309045,0.5883,0.00000269037,0.0001151363,0.00003926191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986473,0.0008026765,0.0002935699,0.000009711956,0.00006805519,0.0001418709,0.000001724865,0.000001678478,0.00003335366],"genre_scores_gemma":[0.9951657,0.0001104171,0.0045818,0.000001426527,0.00004157087,0.000008251572,0.00003382517,0.000005898358,0.00005110947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008637891,"threshold_uncertainty_score":0.2484228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314233626520992,"score_gpt":0.2533268614587991,"score_spread":0.2401845251935892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}