{"id":"W2157997719","doi":"10.1006/jmbi.2001.4628","title":"Antibody recognition of a conformational epitope in a peptide antigen: Fv-peptide complex of an antibody fragment specific for the mutant EGF receptor, EGFRvIII","year":2001,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Regional Cancer Foundation; University of Ottawa","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; National Institute for Health and Care Research","keywords":"Epitope; Peptide; Antigen; Chemistry; Mutant; Linear epitope; Conformational epitope; Molecular biology; Antibody; Receptor; Residue (chemistry); T-cell receptor; Fusion protein; Biology; Biochemistry; Recombinant DNA; T cell; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003338034,0.000286401,0.000292757,0.0002042631,0.0002666553,0.0003197497,0.0004504543,0.0005406136,0.001650515],"category_scores_gemma":[0.0003538073,0.0001827691,0.0003249036,0.0001032311,0.0002176415,0.0002307321,0.0002621161,0.0007576481,0.0003314242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005482915,"about_ca_system_score_gemma":0.0002165131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007697399,"about_ca_topic_score_gemma":0.00090632,"domain_scores_codex":[0.9998013,0.0000388741,0.000008931422,0.00003561975,0.00003725808,0.00007791093],"domain_scores_gemma":[0.9997831,0.00009421723,0.00001953755,0.00001852325,0.00002469713,0.0000599388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002189023,0.00004124875,0.0002282049,0.00001882537,0.0000105693,0.0001471938,0.00001947621,0.0001219246,0.9982168,0.0002047311,0.00004420069,0.0007278526],"study_design_scores_gemma":[0.0001074219,0.0004468969,0.004154165,0.000009718194,0.00003356111,0.0009330467,0.00003379397,0.002837128,0.9901599,0.0001173173,0.001157989,0.000009072462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970623,0.0002280216,0.001838622,0.00005842935,0.00001791922,0.00001066104,0.00002431634,0.0000109072,0.0007488221],"genre_scores_gemma":[0.9978483,0.00012149,0.001024812,0.0000601825,0.00001036843,0.00000619921,0.0001302373,0.000007022348,0.0007915003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001650515,"threshold_uncertainty_score":0.005521536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05043633256753489,"score_gpt":0.3750934783882792,"score_spread":0.3246571458207443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}