{"id":"W2158007655","doi":"10.1172/jci37176","title":"Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; National Center for Research Resources; Broad Institute","keywords":"Lipase; Nonsynonymous substitution; Biology; Cholesterol; Mutation; Internal medicine; Endocrinology; Genetics; Enzyme; Biochemistry; Medicine; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005070693,0.0005177667,0.0005312068,0.0007849232,0.0003182926,0.0004030925,0.0002798738,0.0006456428,0.001539497],"category_scores_gemma":[0.001409184,0.0002264203,0.0002901686,0.0008399992,0.000438946,0.0002203259,0.0002124901,0.0005152684,0.0002161793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396977,"about_ca_system_score_gemma":0.00009490422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005581125,"about_ca_topic_score_gemma":0.0003519739,"domain_scores_codex":[0.999612,0.00009866045,0.00004979445,0.0001232907,0.00008332895,0.00003295744],"domain_scores_gemma":[0.9995638,0.0001252448,0.000177817,0.00005838047,0.00003544272,0.00003947072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003384505,0.0002493925,0.918773,0.0001730973,0.001286019,0.007744949,0.0001740473,0.0006045533,0.03784977,0.0006568581,0.001143862,0.02795989],"study_design_scores_gemma":[0.0001985688,0.0005022787,0.963458,0.00005402798,0.0009857682,0.02464529,0.0001216516,0.001271956,0.004942837,0.001940137,0.00185309,0.00002645532],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951856,0.00207872,0.001060752,0.0002735751,0.00002575274,0.00001144597,0.0003189803,0.00003660995,0.001008645],"genre_scores_gemma":[0.9987865,0.0004653503,0.0003065332,0.00008308556,0.00004913014,0.000004699536,0.0001511972,0.000004843383,0.000148754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539497,"threshold_uncertainty_score":0.005150139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07333857289274275,"score_gpt":0.3547129321314933,"score_spread":0.2813743592387505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}