{"id":"W2158026627","doi":"10.1186/s13293-014-0014-6","title":"Estrogen receptor beta and truncated variants enhance the expression of transfected MMP-1 promoter constructs in response to specific mechanical loading","year":2014,"lang":"en","type":"article","venue":"Biology of Sex Differences","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Arthritis Society","keywords":"Transfection; Estrogen; Estrogen receptor; Human physiology; Matrix metalloproteinase; Receptor; BETA (programming language); Estrogen receptor beta; Medicine; Endocrinology; Internal medicine; Biology; Molecular biology; Cell biology; Cancer research; Chemistry; Genetics; Gene; Computer science; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004511063,0.0004826389,0.0003541503,0.0003465763,0.000162176,0.0003779428,0.0003534259,0.0003627796,0.002505699],"category_scores_gemma":[0.0001983129,0.0003011261,0.0004800535,0.0003184713,0.0003403287,0.0001950706,0.0002740473,0.0008159913,0.0007228595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003635788,"about_ca_system_score_gemma":0.0002448843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005171722,"about_ca_topic_score_gemma":0.0009922473,"domain_scores_codex":[0.9995054,0.00008102195,0.00007878662,0.0001192351,0.0001106403,0.0001048913],"domain_scores_gemma":[0.9997569,0.00007355087,0.00006419345,0.00003680713,0.00002194648,0.00004659327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001269801,0.00006510067,0.00007235681,0.00003802996,0.000004109477,0.00001967122,0.00002379795,0.00003370181,0.9990595,0.00006760592,0.000043417,0.0004456465],"study_design_scores_gemma":[0.00004154728,0.0006752291,0.003275995,0.00001983034,0.00002242516,0.000184507,0.00004770916,0.001051506,0.9912183,0.00004414502,0.003410376,0.000008386513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884894,0.002193317,0.005180405,0.0001766194,0.0001268055,0.0001066494,0.001323544,0.000123053,0.002280261],"genre_scores_gemma":[0.9734538,0.001872111,0.01047426,0.000163396,0.00005021702,0.0002436143,0.004666448,0.00006952144,0.009006534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002505699,"threshold_uncertainty_score":0.00838238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710139767909578,"score_gpt":0.2567875578359239,"score_spread":0.2396861601568282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}