{"id":"W2158039152","doi":"10.1093/hmg/ddv136","title":"Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Bromodomain; BRD4; PKD1; Cancer research; Epigenetics; Autosomal dominant polycystic kidney disease; Biology; BET inhibitor; Cell biology; Chemistry; Molecular biology; Kidney; Endocrinology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160044,0.0002095899,0.0005130686,0.0002336296,0.0001748587,0.0002628564,0.0002663908,0.0003178401,0.0005961322],"category_scores_gemma":[0.000141987,0.0001472502,0.0001857907,0.000108851,0.0002795724,0.000232134,0.0001538329,0.0006053324,0.0001179662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078355,"about_ca_system_score_gemma":0.0002253684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295884,"about_ca_topic_score_gemma":0.0007217561,"domain_scores_codex":[0.9999213,0.00001285079,0.000009374806,0.00001390334,0.00002375422,0.00001878783],"domain_scores_gemma":[0.9999366,0.00001311201,0.00001955514,0.000004905987,0.000006000419,0.00001983838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007963981,0.0001584473,0.0004186184,0.0001135681,0.00001217934,0.0001522467,0.00002419471,0.0003042993,0.9925293,0.0001290124,0.00008451319,0.005277082],"study_design_scores_gemma":[0.0004415876,0.00451363,0.007532581,0.00001584358,0.0000554884,0.001184241,0.00007142968,0.002766651,0.9764642,0.0001748969,0.006759587,0.00001975839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950146,0.001877524,0.002168574,0.0001588536,0.00004922128,0.00003551686,0.0001078461,0.0001011277,0.0004866773],"genre_scores_gemma":[0.9957838,0.001091901,0.002080987,0.00006375847,0.00001079519,0.00003104792,0.0001526554,0.00001226686,0.0007729303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005961322,"threshold_uncertainty_score":0.002233446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923823879221673,"score_gpt":0.2601212373851926,"score_spread":0.2408829985929759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}