{"id":"W2158045389","doi":"10.1093/infdis/jiu014","title":"Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose","year":2014,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Virology; Chikungunya; Alphavirus; Viremia; Attenuated vaccine; Vaccination; Virus; Internal ribosome entry site; Biology; Immunology; Medicine; Virulence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003637807,0.0003187717,0.0006218308,0.0003035677,0.0003258009,0.000123163,0.0001950711,0.00005638143,0.00002944514],"category_scores_gemma":[0.001160062,0.000197699,0.0003945504,0.0004139864,0.00006425522,0.0002081335,0.00007984055,0.0002641693,0.000007785457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234539,"about_ca_system_score_gemma":0.0002155711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006932494,"about_ca_topic_score_gemma":0.000007720894,"domain_scores_codex":[0.997979,0.0002165289,0.0006180553,0.0002325611,0.0005574048,0.0003963892],"domain_scores_gemma":[0.9976254,0.0002747923,0.0005121668,0.0004132635,0.0003438887,0.0008305112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007614345,0.003050627,0.9148483,0.0006843358,0.002007992,0.0005618957,0.0004909327,0.0001901022,0.02101905,0.00004645971,0.003558128,0.04592781],"study_design_scores_gemma":[0.01360272,0.002663142,0.9731979,0.0007265464,0.004639654,0.0001453992,0.0001089815,0.001851066,0.0007976764,0.0005364135,0.001281697,0.0004488287],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916328,0.005546344,0.0001683825,0.001465927,0.0002238611,0.0006987764,0.00003547923,0.0000826162,0.0001458157],"genre_scores_gemma":[0.9972997,0.0003237792,0.00002403298,0.001511273,0.0006962057,0.00002239864,0.0000136125,0.00005095382,0.0000580143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05834956,"threshold_uncertainty_score":0.8061929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005277822139612334,"score_gpt":0.2355058928883606,"score_spread":0.2302280707487483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}