{"id":"W2158045389","doi":"10.1093/infdis/jiu014","title":"Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose","year":2014,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Virology; Chikungunya; Alphavirus; Viremia; Attenuated vaccine; Vaccination; Virus; Internal ribosome entry site; Biology; Immunology; Medicine; Virulence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407723,0.0003852812,0.0003739503,0.000202878,0.0002292381,0.0001978738,0.0002525192,0.0004306977,0.001904264],"category_scores_gemma":[0.0001142388,0.0001350381,0.0002010383,0.0001016346,0.0003142989,0.0002008509,0.0001773651,0.0007309532,0.0003226942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174304,"about_ca_system_score_gemma":0.0001809415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003518217,"about_ca_topic_score_gemma":0.0005632505,"domain_scores_codex":[0.9998527,0.00002492036,0.000008943489,0.00004439798,0.00003319536,0.0000358347],"domain_scores_gemma":[0.9999502,0.000005245472,0.00001368115,0.00000824361,0.000006733804,0.00001596988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004102945,0.0002009941,0.000232144,0.00005812821,0.000007806091,0.0000587976,0.00003060616,0.0001196955,0.9956871,0.0001449367,0.0000836972,0.002965773],"study_design_scores_gemma":[0.0002588473,0.008953271,0.007491814,0.00003002829,0.0000522986,0.0009355819,0.00006727201,0.001604608,0.9720654,0.0001977329,0.008326367,0.00001672747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954563,0.0007987354,0.001639064,0.00007844559,0.00004304412,0.0001469006,0.0002932574,0.00007627013,0.001467878],"genre_scores_gemma":[0.9906582,0.0005859865,0.003745737,0.00006733805,0.00001830353,0.0002255287,0.0009038535,0.00002041182,0.003774735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001904264,"threshold_uncertainty_score":0.006370425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005277822139612334,"score_gpt":0.2355058928883606,"score_spread":0.2302280707487483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}